SH2D3A and ITGB8

		SH2D3A	ITGB8
Description		SH2 domain containing 3A	integrin subunit beta 8
Image		No pdb structure
GO Annotations	Cellular Component		Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta8 Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Integrin Binding Metal Ion Binding Extracellular Matrix Protein Binding
	Biological Process	JNK Cascade Small GTPase-mediated Signal Transduction	Vasculogenesis Ganglioside Metabolic Process Immune Response Cell Adhesion Cell-matrix Adhesion Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration Cell Differentiation Cell Adhesion Mediated By Integrin Positive Regulation Of Angiogenesis Cartilage Development Hard Palate Development Placenta Blood Vessel Development Langerhans Cell Differentiation Cell-cell Adhesion
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions TGF-beta receptor signaling activates SMADs
Drugs
Diseases
GWAS			A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 31959851 31619474 31361310 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Eosinophil count ( 29403010 32888494) Eosinophil percentage of white cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Prostate cancer ( 29892016) Type 1 diabetes ( 34012112) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: BCAR1 CENPB EGFR ERBB2 ERBB3 GAB1 NXF1	6 interacting genes: DYRK1A ITGAV PPP1CA PPP1R9B TGFB1 VTN
Entrez ID		10045	3696
HPRD ID		05283	05001
Ensembl ID		ENSG00000125731	ENSG00000105855
Uniprot IDs		A8K2M8 Q9BRG2	P26012 Q9BUG9
PDB IDs			6DJP 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8TCF 8VS6 8VSD 9IND
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB2 Signaling Pathway ERBB3:ERBB2 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ErbB-3 Class Receptor Binding Basal Plasma Membrane ERBB2-EGFR Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Tyrosine Kinase Activator Activity Protein Tyrosine Kinase Activity Schwann Cell Development Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transmembrane Signaling Receptor Activity Basolateral Plasma Membrane Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle G1/S Phase Transition Response To Growth Factor Multivesicular Body, Internal Vesicle Lumen Regulation Of Angiogenesis Glial Cell Development Ribonucleoside-diphosphate Reductase Activity Regulation Of Vasculature Development Wound Healing Neuron Differentiation Cell Migration Insulin Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Growth Ruffle Membrane Focal Adhesion Shc-EGFR Complex Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development	Histone H3T45 Kinase Activity Semicircular Canal Formation Entry Into Host Cell By A Symbiont-containing Vacuole Endodermal Cell Differentiation Extracellular Matrix Binding Opsonin Binding Cell Adhesion Mediated By Integrin Protein Phosphatase 1 Binding Protein Phosphatase Type 1 Complex Response To Ketone L-phosphoserine Phosphatase Activity Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Liver Regeneration Regulation Of Exit From Mitosis Response To Immobilization Stress Cellular Response To Acetaldehyde Symbiont-containing Vacuole Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Animal Organ Regeneration Inner Ear Development Regulation Of Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining
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