KRTAP9-2 and CYP21A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP9-2	CYP21A2
Description		keratin associated protein 9-2	cytochrome P450 family 21 subfamily A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Monooxygenase Activity Steroid 21-monooxygenase Activity Steroid Binding Iron Ion Binding Lipid Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding 17-hydroxyprogesterone 21-hydroxylase Activity Progesterone 21-hydroxylase Activity
	Biological Process		Lipid Metabolic Process Steroid Biosynthetic Process Glucocorticoid Biosynthetic Process Mineralocorticoid Biosynthetic Process Steroid Metabolic Process Sterol Metabolic Process Cortisol Biosynthetic Process
Pathways		Keratinization	Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP21A2 causes AH3
Drugs			Ketoconazole
Diseases			46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Congenital adrenal hyperplasia (CAH)
GWAS			Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clostridioides difficle infection ( 33841421) Diastolic blood pressure ( 25249183) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 25249183) Inflammatory bowel disease ( 28067908) Postoperative atrial fibrillation in coronary artery bypass grafting surgery ( 26385043) Prostate cancer ( 23535732) Systolic blood pressure ( 25249183) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		146 interacting genes: ADAM12 ADAMTSL4 AGXT AQP1 ARFGAP1 ATG9A AXIN2 C22orf39 CARD10 CATSPER1 CCDC28A CERK CHRD CNNM3 COL8A1 CRCT1 CREB5 CTRC CYP21A2 CYSRT1 DMRT3 DOCK2 FAM76B FBXO34 GATA1 GEMIN4 GLRX3 GNE GNG13 GUCD1 HAPLN2 HOXA1 ITGB4 JOSD1 KLHL38 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP17-1 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-3 KRTAP9-4 KRTAP9-8 LBX1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LMNTD2 LNX1 LYVE1 MAPKBP1 MEOX2 MGAT5B NBPF19 NOTCH2NLA NR1D2 NR4A3 NTAQ1 NUFIP2 OTX1 P2RY6 P3H3 PDE9A PHLDA1 PIGS PLLP PLSCR1 POTEB3 POU4F2 PRKAB2 PRKAG1 PTPMT1 RCHY1 RNF31 RNF8 SDC3 SHFL SLC13A5 SLC39A7 SMCP SPATA3 SPATA8 SPRY1 SPRY2 SUMO1P1 TFAP2D TMEM190 TMSB10 TRIM54 TSPAN4 TYRO3 VASN VGLL3 ZDHHC1 ZDHHC17 ZNF20 ZNF575 ZNF696	21 interacting genes: CRCT1 CREB5 CYSRT1 HOXA1 KRTAP1-3 KRTAP4-2 KRTAP9-2 LCE1D LCE1F LCE2C LCE3B LCE3C LCE3D LCE5A NBPF19 NOTCH2NLA NR4A3 NUFIP2 PICK1 POTEB3 POU4F2
Entrez ID		83899	1589
HPRD ID		13949	01942
Ensembl ID		ENSG00000239886	ENSG00000231852
Uniprot IDs		A0A140TA58 Q9BYQ4	P08686 Q08AG9
PDB IDs			4Y8W 5VBU
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Protein Binding Hair Cycle Identical Protein Binding Regulation Of Neurotrophin TRK Receptor Signaling Pathway	Keratinization Epidermis Development Tissue Development Identical Protein Binding CAMP Response Element Binding Keratin Filament Neuromuscular Process
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