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ADA and TINF2
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
ADA
TINF2
Description
adenosine deaminase
TERF1 interacting nuclear factor 2
Image
GO Annotations
Cellular Component
Cytoplasm
Lysosome
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Vesicle
Cytoplasmic Vesicle Lumen
Anchoring Junction
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Perinucleolar Chromocenter
Nuclear Matrix
Nuclear Body
Shelterin Complex
Molecular Function
Adenosine Deaminase Activity
Protein Binding
Zinc Ion Binding
Hydrolase Activity
Deaminase Activity
Metal Ion Binding
2'-deoxyadenosine Deaminase Activity
DNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
Allantoin Metabolic Process
Response To Hypoxia
In Utero Embryonic Development
Trophectodermal Cell Differentiation
Liver Development
Placenta Development
Germinal Center B Cell Differentiation
Germinal Center Formation
Positive Regulation Of Germinal Center Formation
Negative Regulation Of Leukocyte Migration
Mature B Cell Apoptotic Process
Negative Regulation Of Mature B Cell Apoptotic Process
Adenosine Catabolic Process
Deoxyadenosine Catabolic Process
AMP Catabolic Process
Xenobiotic Metabolic Process
Apoptotic Process
Smooth Muscle Contraction
Cell Adhesion
Nucleotide Metabolic Process
Purine Ribonucleoside Monophosphate Biosynthetic Process
Positive Regulation Of Heart Rate
Response To Purine-containing Compound
Calcium-mediated Signaling
T Cell Differentiation
Lung Development
Positive Regulation Of B Cell Proliferation
Purine Nucleotide Salvage
GMP Salvage
T Cell Differentiation In Thymus
Positive Regulation Of T Cell Differentiation In Thymus
Regulation Of Cell-cell Adhesion Mediated By Integrin
B Cell Proliferation
T Cell Activation
Negative Regulation Of Apoptotic Process
Penile Erection
Purine-containing Compound Salvage
Hypoxanthine Salvage
Amide Catabolic Process
AMP Salvage
Regulation Of Circadian Sleep/wake Cycle, Sleep
Regulation Of T Cell Differentiation
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Smooth Muscle Contraction
DAMP Catabolic Process
DATP Catabolic Process
Adenosine Metabolic Process
Hypoxanthine Biosynthetic Process
Inosine Biosynthetic Process
Xanthine Biosynthetic Process
Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Differentiation
Lung Alveolus Development
Peyer's Patch Development
Embryonic Digestive Tract Development
Negative Regulation Of Inflammatory Response
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Leukocyte Migration
Negative Regulation Of Adenosine Receptor Signaling Pathway
Negative Regulation Of Penile Erection
Thymocyte Apoptotic Process
Negative Regulation Of Thymocyte Apoptotic Process
Mucus Secretion
Negative Regulation Of Mucus Secretion
Telomere Capping
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromosome, Telomeric Region
Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways
Purine salvage
Defective ADA disrupts (deoxy)adenosine deamination
Ribavirin ADME
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Pentostatin
Dipyridamole
FR221647
7,8-dihydroinosine
FR117016
FR236913
6-hydroxy-1,6-dihydro purine nucleoside
FR-234938
FR239087
FR230513
1-Deaza-Adenosine
Nebularine
(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE
1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases
T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS
Inflammatory bowel disease (
28067908
)
Serum metabolite levels (
33031748
)
Ulcerative colitis (
23128233
28067908
)
Leukocyte telomere length (
31171785
)
Platelet count (
29403010
)
Interacting Genes
11 interacting genes:
ADORA1
ADORA2A
ADORA2B
DPP4
DRD1
GRB2
NR3C1
PIAS2
SGCD
TERF2IP
TINF2
91 interacting genes:
ACD
ACOT7
ACTB
ADA
AFAP1L2
AIPL1
AK1
ANKMY2
ANXA4
ANXA5
ANXA8L1
APOBEC3F
APPL2
ARHGDIA
ARID3B
BAG3
BIN2
CALD1
CCDC43
CCDC9
CKB
CLK3
CPNE3
CRYGS
CSNK2A1
CTTN
DBN1
DCX
DHFR2
DPP3
EEF1D
EIF4B
ENO2
FAM131B
FERMT3
FKBP6
GAPDH
GNMT
HNMT
HOXA3
HSP90AB1
IPO5
KCTD17
LASP1
LDHA
LGALSL
LTA4H
MAP2K3
MTNR1B
NCDN
NOL3
NUDC
NUDCD2
OR2H1
PAGE2
PAK1IP1
PEX5
PFKP
PGM1
PGM2
PHPT1
PKM
PPP1R2
PPP6R3
PRKCB
REM2
RGS14
RPSA
SARS1
SCRN2
SIAH2
STUB1
SULT1C2
TAGLN
TBL1X
TERF1
TERF2
TFRC
TOMM34
TPP1
TRIM15
TRIM16
TRIP10
TUBB
TUBB4B
TXNDC17
UCHL1
VIPR1
YWHAG
ZFP36L1
ZNF790
Entrez ID
100
26277
HPRD ID
00038
16056
Ensembl ID
ENSG00000196839
ENSG00000092330
Uniprot IDs
A0A0S2Z381
F5GWI4
P00813
B4DFJ1
Q9BSI4
PDB IDs
3IAR
7RTG
3BQO
3BU8
5XYF
Enriched GO Terms of Interacting Partners
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G Protein-coupled Adenosine Receptor Activity
G Protein-coupled Adenosine Receptor Signaling Pathway
Vasodilation
Purinergic Nucleotide Receptor Signaling Pathway
Circulatory System Process
Blood Vessel Diameter Maintenance
Regulation Of Tube Size
Presynaptic Modulation Of Chemical Synaptic Transmission
Synaptic Transmission, Glutamatergic
Shelterin Complex
Heterotrimeric G-protein Binding
Defense Response
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Regulation Of Synaptic Transmission, Glutamatergic
Nuclear Telomere Cap Complex
Regulation Of Amine Transport
Vascular Process In Circulatory System
Protein Localization To Chromosome, Telomeric Region
Response To Stress
Telomere Capping
Asymmetric Synapse
Axolemma
Maternal Behavior
Prepulse Inhibition
Synaptic Transmission, Dopaminergic
Parental Behavior
Long-term Synaptic Depression
Regulation Of Glutamate Secretion
Regulation Of Circadian Sleep/wake Cycle, Sleep
G Protein-coupled Receptor Activity
Presynaptic Membrane
Regulation Of Circadian Sleep/wake Cycle
Positive Regulation Of Synaptic Transmission
Regulation Of Intracellular Signal Transduction
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Motor Behavior
Telomeric DNA Binding
Endocytosis
Response To Amphetamine
Positive Regulation Of Synaptic Transmission, Glutamatergic
Reproductive Behavior
Positive Regulation Of Potassium Ion Transport
Regulation Of Synaptic Transmission, GABAergic
Temperature Homeostasis
Modulation Of Chemical Synaptic Transmission
Locomotory Behavior
Behavioral Fear Response
Behavioral Defense Response
Negative Regulation Of Synaptic Transmission
Negative Regulation Of Telomere Maintenance
Cytosol
Extracellular Exosome
Cytoplasm
ADP Metabolic Process
Purine Ribonucleotide Catabolic Process
Ribonucleoside Diphosphate Metabolic Process
Glycolytic Process
ADP Catabolic Process
Purine Nucleotide Catabolic Process
Nucleoside Phosphate Catabolic Process
Nucleoside Diphosphate Metabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Ribonucleoside Diphosphate Catabolic Process
Nucleoside Diphosphate Catabolic Process
Cadherin Binding
Pyruvate Metabolic Process
Nucleotide Catabolic Process
Carbohydrate Catabolic Process
Shelterin Complex
Organophosphate Catabolic Process
Glucose Metabolic Process
RNA-templated DNA Biosynthetic Process
Nuclear Telomere Cap Complex
Glucose Catabolic Process
Nucleobase-containing Compound Catabolic Process
Protein Localization To Chromosome, Telomeric Region
ATP Metabolic Process
Hexose Metabolic Process
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Telomere Capping
Nicotinamide Nucleotide Metabolic Process
Purine-containing Compound Metabolic Process
Generation Of Precursor Metabolites And Energy
Ficolin-1-rich Granule Lumen
Nucleobase-containing Small Molecule Metabolic Process
Monosaccharide Metabolic Process
Carbohydrate Derivative Catabolic Process
Phosphoglucomutase Activity
Nucleoside Metabolic Process
Protein Binding
Purine Ribonucleotide Metabolic Process
Calcium-dependent Phospholipid Binding
Cellular Response To Heat
Canonical Glycolysis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Ribonucleotide Metabolic Process
Glycolytic Process Through Glucose-6-phosphate
Glycolytic Process Through Fructose-6-phosphate
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