ADA

Name	adenosine deaminase
Structure
Novel Interactors	1 novel interactors: WFDC12
Interactors	11 interactors: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Lumen Anchoring Junction
	Molecular Function	Adenosine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deaminase Activity Metal Ion Binding 2'-deoxyadenosine Deaminase Activity
	Biological Process	Allantoin Metabolic Process Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Germinal Center Formation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Mature B Cell Apoptotic Process Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process AMP Catabolic Process Xenobiotic Metabolic Process Apoptotic Process Smooth Muscle Contraction Cell Adhesion Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Response To Purine-containing Compound Calcium-mediated Signaling T Cell Differentiation Lung Development Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage GMP Salvage T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Penile Erection Purine-containing Compound Salvage Hypoxanthine Salvage Amide Catabolic Process AMP Salvage Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Adenosine Metabolic Process Hypoxanthine Biosynthetic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Mucus Secretion Negative Regulation Of Mucus Secretion
Pathways	Purine salvage Defective ADA disrupts (deoxy)adenosine deamination Ribavirin ADME
Drugs	Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases	T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS	Inflammatory bowel disease ( 28067908 ) Serum metabolite levels ( 33031748 ) Ulcerative colitis ( 23128233 28067908 )
Entrez ID	100
HPRD ID	00038
Ensembl ID	ENSG00000196839
Uniprot IDs	A0A0S2Z381 F5GWI4 P00813
PDB IDs	3IAR 7RTG
GO Terms Enriched among Interactors ?	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Adenosine Receptor Signaling Pathway Vasodilation Purinergic Nucleotide Receptor Signaling Pathway Circulatory System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Shelterin Complex Heterotrimeric G-protein Binding Defense Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Nuclear Telomere Cap Complex Regulation Of Amine Transport Vascular Process In Circulatory System Protein Localization To Chromosome, Telomeric Region Response To Stress Telomere Capping Asymmetric Synapse Axolemma Maternal Behavior Prepulse Inhibition Synaptic Transmission, Dopaminergic Parental Behavior Long-term Synaptic Depression Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Activity Presynaptic Membrane Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Synaptic Transmission Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Motor Behavior Telomeric DNA Binding Endocytosis Response To Amphetamine Positive Regulation Of Synaptic Transmission, Glutamatergic Reproductive Behavior Positive Regulation Of Potassium Ion Transport Regulation Of Synaptic Transmission, GABAergic Temperature Homeostasis Modulation Of Chemical Synaptic Transmission Locomotory Behavior Behavioral Fear Response Behavioral Defense Response Negative Regulation Of Synaptic Transmission Negative Regulation Of Telomere Maintenance