ADA and DRD1

Number of citations of the paper that reports this interaction (PubMedID 12150791)
0

Data Source:
HPRD (in vitro)

		ADA	DRD1
Description		adenosine deaminase	dopamine receptor D1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Cytoplasmic Vesicle Lumen Anchoring Junction	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cilium Endomembrane System Membrane Dendrite Presynaptic Membrane Cell Projection Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Adenosine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Deaminase Activity Metal Ion Binding 2'-deoxyadenosine Deaminase Activity	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Heterotrimeric G-protein Binding Dopamine Binding Arrestin Family Protein Binding
	Biological Process	Allantoin Metabolic Process Response To Hypoxia In Utero Embryonic Development Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Germinal Center Formation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Mature B Cell Apoptotic Process Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process AMP Catabolic Process Xenobiotic Metabolic Process Apoptotic Process Smooth Muscle Contraction Cell Adhesion Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Response To Purine-containing Compound Calcium-mediated Signaling T Cell Differentiation Lung Development Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage GMP Salvage T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Proliferation T Cell Activation Negative Regulation Of Apoptotic Process Penile Erection Purine-containing Compound Salvage Hypoxanthine Salvage Amide Catabolic Process AMP Salvage Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Adenosine Metabolic Process Hypoxanthine Biosynthetic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Mucus Secretion Negative Regulation Of Mucus Secretion	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Neuron Migration Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Synapse Assembly Learning Memory Mating Behavior Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Associative Learning Visual Learning Response To Xenobiotic Stimulus Astrocyte Development Dopamine Transport Cell Migration Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Hippocampus Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Synaptic Transmission, Glutamatergic Regulation Of Dopamine Metabolic Process Response To Cocaine Vasodilation Dopamine Metabolic Process Maternal Behavior Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAPK Cascade D-glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Modification Of Postsynaptic Structure Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neuron Migration
Pathways		Purine salvage Defective ADA disrupts (deoxy)adenosine deamination Ribavirin ADME	Dopamine receptors G alpha (s) signalling events
Drugs		Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE	Ziprasidone Cabergoline Cabergoline Olanzapine Olanzapine Methylergometrine Clozapine Phenylpropanolamine Loxapine Loxapine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Periciazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Lumateperone Mianserin Asenapine Nandrolone decanoate Quinagolide Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pipradrol Tetrahydropalmatine Dihydrexidine Dihydroergocristine Aripiprazole lauroxil
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Inflammatory bowel disease ( 28067908) Serum metabolite levels ( 33031748) Ulcerative colitis ( 23128233 28067908)	Cadmium levels ( 26025379) Chin dimples ( 27182965) Falling risk ( 32999390) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		11 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2	19 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DLG4 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 MEIS2 PDCD6IP PRKACA TGIF1 VPS35
Entrez ID		100	1812
HPRD ID		00038	00538
Ensembl ID		ENSG00000196839	ENSG00000184845
Uniprot IDs		A0A0S2Z381 F5GWI4 P00813	P21728
PDB IDs		3IAR 7RTG	7CKW 7CKX 7CKY 7CKZ 7CRH 7F0T 7F1O 7F1Z 7F23 7F24 7JOZ 7JV5 7JVP 7JVQ 7LJC 7LJD 7X2C 7X2D 7X2F 8IRR 8JXR 8JXS
Enriched GO Terms of Interacting Partners?		G Protein-coupled Adenosine Receptor Activity G Protein-coupled Adenosine Receptor Signaling Pathway Vasodilation Purinergic Nucleotide Receptor Signaling Pathway Circulatory System Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Transmission, Glutamatergic Shelterin Complex Heterotrimeric G-protein Binding Defense Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Nuclear Telomere Cap Complex Regulation Of Amine Transport Vascular Process In Circulatory System Protein Localization To Chromosome, Telomeric Region Response To Stress Telomere Capping Asymmetric Synapse Axolemma Maternal Behavior Prepulse Inhibition Synaptic Transmission, Dopaminergic Parental Behavior Long-term Synaptic Depression Regulation Of Glutamate Secretion Regulation Of Circadian Sleep/wake Cycle, Sleep G Protein-coupled Receptor Activity Presynaptic Membrane Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Synaptic Transmission Regulation Of Intracellular Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Motor Behavior Telomeric DNA Binding Endocytosis Response To Amphetamine Positive Regulation Of Synaptic Transmission, Glutamatergic Reproductive Behavior Positive Regulation Of Potassium Ion Transport Regulation Of Synaptic Transmission, GABAergic Temperature Homeostasis Modulation Of Chemical Synaptic Transmission Locomotory Behavior Behavioral Fear Response Behavioral Defense Response Negative Regulation Of Synaptic Transmission Negative Regulation Of Telomere Maintenance	Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Behavior Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway D1 Dopamine Receptor Binding Regulation Of Transport Regulation Of Dopamine Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Secretion Cognition Negative Regulation Of Mucus Secretion Positive Regulation Of Signal Transduction Regulation Of Secretion Establishment Of Protein Localization Postsynapse Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Process System Process Learning Or Memory Membrane Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Regulation Of System Process Glutamatergic Synapse Heterotrimeric G-protein Binding Regulation Of Secretion By Cell Learning Nervous System Process Visual Learning Regulation Of Metal Ion Transport Regulation Of Mucus Secretion Negative Regulation Of Secretion Regulation Of Muscle Contraction Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Negative Regulation Of Synaptic Transmission, Glutamatergic Visual Behavior Synaptic Membrane Cell Communication Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Receptor Internalization
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