ADA and ADORA2A

Number of citations of the paper that reports this interaction (PMID 11125033)
14

Data Source:
HPRD (in vivo)

		ADA	ADORA2A
Gene Name		adenosine deaminase	adenosine A2a receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Membrane-bounded Vesicle Lumen	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding	G-protein Coupled Adenosine Receptor Activity Protein Binding Enzyme Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Purine Nucleobase Metabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Drug Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion	Adenosine Receptor Signaling Pathway CAMP Biosynthetic Process Phagocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Central Nervous System Development Blood Coagulation Sensory Perception Blood Circulation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway
Pathways		Purine metabolism Metabolism of nucleotides Purine salvage	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Nucleotide-like (purinergic) receptors Activation of TRKA receptors Class A/1 (Rhodopsin-like receptors) NGF signalling via TRKA from the plasma membrane Metabolic disorders of biological oxidation enzymes GPCR ligand binding GPCR downstream signaling NGF-independant TRKA activation Adenosine P1 receptors
Drugs		Pentostatin Dipyridamole FR221647 6-Hydroxy-7,8-Dihydro Purine Nucleoside FR117016 FR236913 6-Hydroxy-1,6-Dihydro Purine Nucleoside FR233623 FR239087 FR230513 1-Deaza-Adenosine Purine Riboside (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE	Caffeine Theophylline Mefloquine Adenosine Dyphylline Pentoxifylline Oxtriphylline Theobromine Defibrotide Regadenoson 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol
Diseases
GWAS		Ulcerative colitis ( 23128233)
Protein-Protein Interactions		11 interactors: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2	8 interactors: ACTN1 ACTN2 ACTN3 ACTN4 ADA CYTH2 DRD2 NAMPT
Entrez ID		100	135
HPRD ID		00038	00043
Ensembl ID		ENSG00000196839	ENSG00000128271
Uniprot IDs		F5GWI4 P00813	A8K1F6 B3KVQ4 P29274
PDB IDs		1M7M 3IAR	1MMH 1UPE 2YDO 2YDV 3EML 3PWH 3QAK 3REY 3RFM 3UZA 3UZC 3VG9 3VGA 4EIY
Enriched GO Terms of Interacting Partners?		Adenosine Receptor Signaling Pathway Blood Circulation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Vasodilation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Metabolic Process Protein Localization To Chromosome, Telomeric Region Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Metabolic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Telomere Maintenance Relaxation Of Vascular Smooth Muscle Regulation Of CAMP Biosynthetic Process Relaxation Of Smooth Muscle Regulation Of CAMP Metabolic Process Maternal Behavior Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Telomere Maintenance Negative Regulation Of Muscle Contraction Relaxation Of Muscle Temperature Homeostasis Positive Regulation Of Potassium Ion Transport Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Signaling Regulation Of Signaling Defense Response Phagocytosis Muscle System Process Response To Stress Regulation Of Smooth Muscle Contraction Cellular Defense Response Positive Regulation Of Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Potassium Ion Transport Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cellular Biosynthetic Process	Protein Localization To Tight Junction Focal Adhesion Assembly Cell Junction Assembly Adherens Junction Assembly Cell-cell Junction Organization Cell-substrate Junction Assembly Negative Regulation Of Cellular Component Movement Secretion Actin Filament-based Process Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Platelet Degranulation Protein Localization To Cell Junction Adherens Junction Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Actin Crosslink Formation Negative Regulation Of Circadian Rhythm Cell-matrix Adhesion Regulation Of Body Fluid Levels Platelet Activation Positive Regulation Of Ion Transport Cell-substrate Adhesion Vesicle-mediated Transport Muscle Contraction Regulation Of Apoptotic Process Cell Activation Regulation Of Cellular Component Movement Response To Wounding Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of Cell Death Muscle System Process Negative Regulation Of Transporter Activity Response To Morphine Actin-mediated Cell Contraction Response To Hypoxia Tight Junction Assembly Negative Regulation Of Ion Transmembrane Transport Positive Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transmembrane Transport Cellular Component Assembly Exocytosis Positive Regulation Of Transporter Activity Regulation Of Potassium Ion Transport Actin Filament Bundle Assembly Actin Filament-based Movement Regulation Of Sodium Ion Transport Negative Regulation Of Transport Apical Junction Assembly
Tagcloud ?		accessibility acetylates acetyltransferases arrays assayed buffer catalytically complexed concomitantly extensively faster folded gcn5 gcn5p hat hats mgcl2 monoacetylates nacl nucleosomal nucleosome nucleosomes optimum particles polyacetylates prefers rgcn5p saga termini	aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding
Tagcloud (Difference) ?		accessibility acetylates acetyltransferases arrays assayed buffer catalytically complexed concomitantly extensively faster folded gcn5 gcn5p hat hats mgcl2 monoacetylates nacl nucleosomal nucleosome nucleosomes optimum particles polyacetylates prefers rgcn5p saga termini	aetio aetiological aetiology amygdala aversive avoid behaviours biologics corticoidism darpp drd2 electroshocks escape fatigue fear fearfulness helplessness hyper manipulations neuropsychiatry paradigm psychopathologies psychosocial socially stressed stressful treadmill uncontrollable wounding
Tagcloud (Intersection) ?