CSF1 and SOCS1

Number of citations: 0 (PubMedID 11297560)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		CSF1	SOCS1
Name		colony stimulating factor 1	suppressor of cytokine signaling 1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity	Protein Kinase Inhibitor Activity Cytokine Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding
	Biological Process	Neutrophil Homeostasis Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Immune System Process Positive Regulation Of Leukocyte Migration Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Monocyte Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Mononuclear Cell Proliferation Monocyte Homeostasis Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Metabolic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Macrophage Homeostasis Myeloid Leukocyte Migration Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration	Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Macrophage Differentiation Developmental Process Intracellular Signal Transduction Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation Signaling by CSF1 (M-CSF) in myeloid cells Transcriptional and post-translational regulation of MITF-M expression and activity	Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Adult onset Still's disease ( 32149159 ) Aspartate aminotransferase levels ( 33547301 33339817 29403010 ) Blood protein levels in cardiovascular risk ( 28369058 ) Creatine kinase levels ( 29403010 ) Cryptococcosis in HIV infection ( 33269293 ) Height ( 31562340 ) High density lipoprotein cholesterol levels ( 33339817 ) Lactate dehydrogenase levels ( 29403010 ) Lymphocyte count ( 32888494 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 32888494 ) Obesity-related traits ( 23251661 ) Paget's disease ( 21623375 20436471 ) Periventricular white matter hyperintensities ( 32517579 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954 ) Serum total protein levels ( 29403010 ) Total body bone mineral density ( 29304378 ) White blood cell count ( 32888494 27863252 )	Allergy ( 27182965 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 31959851 29273806 ) Bulimia nervosa ( 23568457 ) Celiac disease ( 20190752 ) Crohn's disease ( 28067908 ) Crohn's disease and psoriasis ( 22482804 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Inflammatory bowel disease ( 23128233 28067908 ) Multiple sclerosis ( 31604244 ) Primary biliary cholangitis ( 26394269 ) Primary biliary cirrhosis ( 22961000 ) Psoriasis ( 23143594 ) Psoriasis vulgaris ( 26626624 ) Systemic lupus erythematosus ( 27399966 26502338 )
Interacting Genes		13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF	54 interacting genes: AXL BLK COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT LCK LYN MET MIR924HG MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 SRC TEC TEK TIRAP TP53 TRIM8 TYK2 VAV1 VAV2 YES1
Entrez ID		1435	8651
HPRD ID		00388	04669
Ensembl ID		ENSG00000184371	ENSG00000185338
Uniprot IDs		P09603	O15524 Q4JHT5
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF	Not available
GO Terms Enriched among Interactors		Macrophage Differentiation Myeloid Leukocyte Differentiation Response To Macrophage Colony-stimulating Factor Myeloid Cell Differentiation Leukocyte Differentiation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune System Process Protein Phosphorylation Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Phosphorylation Regulation Of Signal Transduction Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process Protein Phosphatase Binding Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of MAPK Cascade Protein Autophosphorylation Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ATP Binding Immune Response-activating Signaling Pathway Positive Regulation Of Metabolic Process Phosphotyrosine Residue Binding Regulation Of Immune Response Plasma Membrane Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility