CSF1 and FHL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CSF1	FHL3
Description		colony stimulating factor 1	four and a half LIM domains 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex	Stress Fiber Nucleus Cytoplasm Focal Adhesion Z Disc
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity	Transcription Coregulator Activity Actin Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Neutrophil Homeostasis Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Immune System Process Positive Regulation Of Leukocyte Migration Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Monocyte Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Mononuclear Cell Proliferation Monocyte Homeostasis Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Metabolic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Macrophage Homeostasis Myeloid Leukocyte Migration Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration	Muscle Organ Development Actin Cytoskeleton Organization
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation Signaling by CSF1 (M-CSF) in myeloid cells Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Cryptococcosis in HIV infection ( 33269293) Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817) Lactate dehydrogenase levels ( 29403010) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein levels ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)	Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF	181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CIMAP1B CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM222B FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GARIN6 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 HYCC1 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYCBP2 MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PIERCE1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SAXO4 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SPMAP2 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 TLE5 TMEM108 TMEM14B TMSB4X TMX3 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587
Entrez ID		1435	2275
HPRD ID		00388	09101
Ensembl ID		ENSG00000184371	ENSG00000183386
Uniprot IDs		P09603	Q13643 Q96C98
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF	1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Myeloid Leukocyte Differentiation Response To Macrophage Colony-stimulating Factor Myeloid Cell Differentiation Leukocyte Differentiation	Protein Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Ventral Spinal Cord Interneuron Differentiation Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Transcription Coregulator Binding DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Phosphatase Binding Positive Regulation Of Macromolecule Metabolic Process Cell Population Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of MiRNA Transcription Identical Protein Binding SMAD Protein Complex Sequence-specific Double-stranded DNA Binding Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Myelination DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axon Ensheathment
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