CSF1 and SLA2

Number of citations of the paper that reports this interaction (PMID 17353186)
4

Data Source:
BioGRID (pull down)

		CSF1	SLA2
Gene Name		colony stimulating factor 1 (macrophage)	Src-like-adaptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Cytoplasm Late Endosome Plasma Membrane Endosome Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Growth Factor Activity Protein Homodimerization Activity	SH3/SH2 Adaptor Activity Protein Binding Protein N-terminus Binding
	Biological Process	Ossification Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Developmental Process Involved In Reproduction Inflammatory Response Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Hemopoiesis Cell Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organism Growth Monocyte Activation Odontogenesis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Signal Transduction B Cell Mediated Immunity Intracellular Receptor Signaling Pathway T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of B Cell Activation
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		10 interactors: CSF1R FHL3 GAB3 HLA-B NOTCH2NL PIK3R2 SGTA SLA2 SOCS1 TNF	6 interactors: CBL CD247 CSF1 ERBB2 LAMC2 ZAP70
Entrez ID		1435	84174
HPRD ID		00388	05955
Ensembl ID		ENSG00000184371	ENSG00000101082
Uniprot IDs		P09603	Q9H6Q3
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Regulation Of Immune Response Myeloid Leukocyte Differentiation Cytokine-mediated Signaling Pathway Macrophage Differentiation Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Response To Cytokine Myeloid Cell Differentiation Positive Regulation Of Chemokine Production Osteoclast Differentiation Innate Immune Response Regulation Of Kinase Activity Regulation Of Chemokine Production Cellular Response To Amino Acid Stimulus Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cytokine Secretion Regulation Of Transcription Factor Import Into Nucleus Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Interleukin-6 Production Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Ketone Metabolic Process Response To Amino Acid Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response	Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Defense Response Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Mammary Gland Fat Development T Cell Receptor Signaling Pathway Positive Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Differentiation Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Beta Selection Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Antigen Receptor-mediated Signaling Pathway Regulation Of T Cell Proliferation Regulation Of Lymphocyte Differentiation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Osteoclast Proliferation Positive Regulation Of Cell Proliferation Immune System Process Regulation Of Immune Response Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Immature T Cell Proliferation In Thymus Response To Fibroblast Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Monocyte Differentiation Mammary Duct Terminal End Bud Growth Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Growth Positive Regulation Of Cell-cell Adhesion Monocyte Activation Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Cell Activation
Tagcloud ?		bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1	adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj finger frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced similarity sin4 ure2 xiv zinc zwf1
Tagcloud (Difference) ?		bands constructs ddpcr encodes escape exceptions g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1	adjacent already bases blh1 cerevisiae correspond cosmid displays dnaj frames globin interesting kex2 motifs n1254 nii42 orf orfs reading remaining saccharomyces sequenced sin4 ure2 xiv zinc zwf1
Tagcloud (Intersection) ?		finger similarity