CSF1 and SLA2

Number of citations of the paper that reports this interaction (PubMedID 17353186)
0

Data Source:
BioGRID (pull down)

		CSF1	SLA2
Description		colony stimulating factor 1	Src like adaptor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane Nuclear Body Perinuclear Region Of Cytoplasm CSF1-CSF1R Complex	Nucleoplasm Cytoplasm Late Endosome Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Endomembrane System Membrane Cytoplasmic Vesicle
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding Signaling Adaptor Activity
	Biological Process	Neutrophil Homeostasis Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Immune System Process Positive Regulation Of Leukocyte Migration Response To Ischemia Developmental Process Involved In Reproduction Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Chemotaxis Monocyte Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Mononuclear Cell Proliferation Monocyte Homeostasis Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Monocyte Activation Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Metabolic Process Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth Microglial Cell Proliferation Macrophage Homeostasis Myeloid Leukocyte Migration Positive Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Microglial Cell Migration Positive Regulation Of Macrophage Migration	Negative Regulation Of Transcription By RNA Polymerase II B Cell Mediated Immunity T Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Other interleukin signaling Interleukin-10 signaling Post-translational protein phosphorylation Signaling by CSF1 (M-CSF) in myeloid cells Transcriptional and post-translational regulation of MITF-M expression and activity	Negative regulation of FLT3
Drugs
Diseases
GWAS		Adult onset Still's disease ( 32149159) Aspartate aminotransferase levels ( 33547301 33339817 29403010) Blood protein levels in cardiovascular risk ( 28369058) Creatine kinase levels ( 29403010) Cryptococcosis in HIV infection ( 33269293) Height ( 31562340) High density lipoprotein cholesterol levels ( 33339817) Lactate dehydrogenase levels ( 29403010) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471) Periventricular white matter hyperintensities ( 32517579) Platelet count ( 32888494) Plateletcrit ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Serum total protein levels ( 29403010) Total body bone mineral density ( 29304378) White blood cell count ( 32888494 27863252)
Interacting Genes		13 interacting genes: CSF1R CYSRT1 FHL3 GAB3 HLA-B KRTAP1-1 KRTAP10-8 MTUS2 NOTCH2NLA SGTA SLA2 SOCS1 TNF	16 interacting genes: CBL CD247 CSF1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT LAMC2 MAP1LC3A MET PRKAA2 UBASH3A ZAP70
Entrez ID		1435	84174
HPRD ID		00388	05955
Ensembl ID		ENSG00000184371	ENSG00000101082
Uniprot IDs		P09603	Q9H6Q3
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8 4WRL 4WRM 5LXF	4M4Z
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Myeloid Leukocyte Differentiation Response To Macrophage Colony-stimulating Factor Myeloid Cell Differentiation Leukocyte Differentiation	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB Signaling Pathway Positive Regulation Of Signal Transduction Receptor Complex Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Transferase Activity Positive Regulation Of Locomotion ERBB3:ERBB2 Complex Regulation Of Cell Migration ATP Binding Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Programmed Cell Death Regulation Of Locomotion Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Nucleotide Binding Protein Tyrosine Kinase Binding Cell Migration Intracellular Signal Transduction Positive Regulation Of Phosphate Metabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Growth Factor Binding
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