CSF1 and GAB3

Number of citations of the paper that reports this interaction (PMID 11739737)
16

Data Source:
HPRD (in vivo)

		CSF1	GAB3
Gene Name		colony stimulating factor 1 (macrophage)	GRB2-associated binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Ossification Positive Regulation Of Cell-matrix Adhesion Osteoclast Proliferation Developmental Process Involved In Reproduction Inflammatory Response Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Hemopoiesis Cell Differentiation Macrophage Differentiation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Multicellular Organism Growth Monocyte Activation Odontogenesis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Ras Protein Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Fat Development Mammary Duct Terminal End Bud Growth	Macrophage Differentiation
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Paget's disease ( 21623375 20436471)
Protein-Protein Interactions		10 interactors: CSF1R FHL3 GAB3 HLA-B NOTCH2NL PIK3R2 SGTA SLA2 SOCS1 TNF	8 interactors: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC
Entrez ID		1435	139716
HPRD ID		00388	06571
Ensembl ID		ENSG00000184371	ENSG00000160219
Uniprot IDs		P09603	A6NHF8 Q8WWW8
PDB IDs		1HMC 3UEZ 3UF2 4ADF 4FA8
Enriched GO Terms of Interacting Partners?		Immune Response Immune System Process Regulation Of Immune Response Myeloid Leukocyte Differentiation Cytokine-mediated Signaling Pathway Macrophage Differentiation Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Transcription Factor Import Into Nucleus Response To Cytokine Myeloid Cell Differentiation Positive Regulation Of Chemokine Production Osteoclast Differentiation Innate Immune Response Regulation Of Kinase Activity Regulation Of Chemokine Production Cellular Response To Amino Acid Stimulus Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Immune System Process Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cytokine Secretion Regulation Of Transcription Factor Import Into Nucleus Regulation Of JAK-STAT Cascade Positive Regulation Of Protein Import Into Nucleus Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Interleukin-6 Production Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Response To Gold Nanoparticle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Ketone Metabolic Process Response To Amino Acid Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response	T Cell Costimulation Positive Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Hemostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Cellular Response To Fibroblast Growth Factor Stimulus Response To Peptide Platelet Activation Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune System Process Cellular Response To Hormone Stimulus Regulation Of Body Fluid Levels Wound Healing Phagocytosis Positive Regulation Of Immune Response Cell Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1	adaptor angiogenesis binders biological consist date diversified docking effector effectors exclusively gab1 gab2 grb2 homology intensively link mediate motifs overview p85 phosphatidylinositol playing rtks sh2 shp2 special transducing
Tagcloud (Difference) ?		bands constructs ddpcr encodes escape exceptions finger g401 genitourinary greatly hek293 indeed influences kidneys lesser none northern saos similarity steady tetracycline thousand transfected transfection tumorigenicity unambiguously verified wilms wt1	adaptor angiogenesis binders biological consist date diversified docking effector effectors exclusively gab1 gab2 grb2 homology intensively link mediate motifs overview p85 phosphatidylinositol playing rtks sh2 shp2 special transducing
Tagcloud (Intersection) ?