PPP4R1 and CEP63

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		PPP4R1	CEP63
Gene Name		protein phosphatase 4, regulatory subunit 1	centrosomal protein 63kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase 4 Complex	Spindle Pole Centrosome Centriole Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Protein Phosphatase Type 4 Regulator Activity	Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Dephosphorylation Regulation Of Catalytic Activity	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Nuclear Division Centriole Replication Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Height ( 18391952)
Protein-Protein Interactions		4 interactors: CEP63 DISC1 HDAC3 PPP4C	44 interactors: ALOX5 ARFIP2 ARNT2 CAMKK2 CCDC14 CCNI CEP57 CEP57L1 DDX26B DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNXL4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TANK TBC1D15 TSHZ3 TXLNA TXLNB USHBP1 ZCCHC10
Entrez ID		9989	80254
HPRD ID		05366	07826
Ensembl ID		ENSG00000154845	ENSG00000182923
Uniprot IDs		Q8TF05	Q96MT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Spindle Assembly Microtubule-based Process Spindle Organization Cytoskeleton Organization Intracellular Signal Transduction Centriole Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Organelle Assembly Signal Transduction Cellular Response To Fluid Shear Stress Mitochondrial Calcium Ion Homeostasis Signaling Regulation Of Synapse Maturation Centriole Assembly Cell Communication Positive Regulation Of TOR Signaling TOR Signaling	Microtubule Cytoskeleton Organization Organelle Organization Cytoskeleton Organization Microtubule-based Process Cell Cycle Process Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Cell Cycle Cellular Localization Golgi To Plasma Membrane Protein Transport Cell Cycle Maintenance Of Protein Location In Cell Maintenance Of Protein Location Brain Development Maintenance Of Location In Cell Protein Localization To Organelle Head Development Anatomical Structure Development Golgi To Plasma Membrane Transport Regulation Of Cellular Component Size Positive Regulation Of Axon Extension Intermediate Filament Cytoskeleton Organization Microtubule Anchoring Protein Localization Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Leukotriene Production Involved In Inflammatory Response Kidney Smooth Muscle Cell Differentiation Ureteric Peristalsis Nervous System Development Intermediate Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Protein Localization To Nucleus Regulation Of Cell Cycle Cell Proliferation In Forebrain Actin Filament Capping Central Nervous System Development Mitotic Cell Cycle Process Cellular Protein Localization Cerebral Cortex Radially Oriented Cell Migration Endomembrane System Organization Negative Regulation Of Actin Filament Depolymerization Developmental Process
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