THOC1 and RABGEF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		THOC1	RABGEF1
Gene Name		THO complex 1	RAB guanine nucleotide exchange factor (GEF) 1
Image
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Intercellular Bridge	Early Endosome Vesicle Recycling Endosome
	Molecular Function	DNA Binding RNA Binding Protein Binding	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Regulation Of DNA Recombination Transcription, DNA-templated RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Bipolar disorder and major depressive disorder (combined) ( 20351715)	Aortic root size ( 21223598)
Protein-Protein Interactions		13 interactors: ALYREF DHX8 FRA10AC1 IK MOAP1 RABGEF1 RB1 SAP30BP SF3B2 THOC5 TRIM54 USHBP1 WDR77	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		9984	27342
HPRD ID		09498	11477
Ensembl ID		ENSG00000079134	ENSG00000243335
Uniprot IDs		Q96FV9	B4DZM7 Q9UJ41
PDB IDs		1WXP	1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Viral Process RNA Metabolic Process Gene Expression Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus Negative Regulation Of Kit Signaling Pathway RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Leukocyte Differentiation Establishment Of Localization In Cell Nuclear Export MRNA Transport Regulation Of Centromere Complex Assembly Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Maintenance Of Mitotic Sister Chromatid Cohesion Protein Insertion Into Mitochondrial Membrane Regulation Of Cohesin Localization To Chromatin Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development RNA Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Negative Regulation Of Interleukin-6 Secretion Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mast Cell Degranulation Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Export From Nucleus Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation Cellular Localization Primitive Hemopoiesis Viral Life Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Intracellular Transport	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated	abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated	abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?