THOC1 and WDR77

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		THOC1	WDR77
Gene Name		THO complex 1	WD repeat domain 77
Image
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Intercellular Bridge	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome
	Molecular Function	DNA Binding RNA Binding Protein Binding	Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Regulation Of DNA Recombination Transcription, DNA-templated RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint	Spliceosomal SnRNP Assembly Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression NcRNA Metabolic Process Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways			Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS		Bipolar disorder and major depressive disorder (combined) ( 20351715)
Protein-Protein Interactions		13 interactors: ALYREF DHX8 FRA10AC1 IK MOAP1 RABGEF1 RB1 SAP30BP SF3B2 THOC5 TRIM54 USHBP1 WDR77	35 interactors: AQR BAG2 COPRS CTDP1 GPKOW HIST2H2AB HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRMT5 QKI RBM5 SAP30BP SF1 SF3A1 SF3B4 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZNF207
Entrez ID		9984	79084
HPRD ID		09498	14387
Ensembl ID		ENSG00000079134	ENSG00000116455
Uniprot IDs		Q96FV9	B4DP38 Q9BQA1
PDB IDs		1WXP	4GQB
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Viral Process RNA Metabolic Process Gene Expression Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus Negative Regulation Of Kit Signaling Pathway RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Leukocyte Differentiation Establishment Of Localization In Cell Nuclear Export MRNA Transport Regulation Of Centromere Complex Assembly Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Maintenance Of Mitotic Sister Chromatid Cohesion Protein Insertion Into Mitochondrial Membrane Regulation Of Cohesin Localization To Chromatin Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development RNA Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Negative Regulation Of Interleukin-6 Secretion Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mast Cell Degranulation Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Export From Nucleus Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation Cellular Localization Primitive Hemopoiesis Viral Life Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Intracellular Transport	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Gene Expression RNA Metabolic Process Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Transcription, DNA-templated Histone MRNA Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Cellular Component Assembly NcRNA Metabolic Process Termination Of RNA Polymerase II Transcription DNA-templated Transcription, Termination MRNA 3'-end Processing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA 3'-end Processing MRNA 3'-splice Site Recognition Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Histone Methylation Regulation Of RNA Metabolic Process MRNA Splice Site Selection Biosynthetic Process Histone H4-R3 Methylation Protein Methylation Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Alternative MRNA Splicing, Via Spliceosome Histone Arginine Methylation Peptidyl-arginine Methylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of RNA Splicing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated	androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Difference) ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated	androgen androgens ar ara70 ara70alpha ara70beta art benign coactivator coactivators corepressor cytoplasmic dysregulation ele1 exhibiting inhibitions internally luciferase mep50 ncoa4 p44 pca promotion spliced suppressive switch switches tblr1 versions
Tagcloud (Intersection) ?