THOC1 and IK

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		THOC1	IK
Gene Name		THO complex 1	IK cytokine, down-regulator of HLA II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck Intercellular Bridge	Extracellular Space Nucleoplasm Nucleolus
	Molecular Function	DNA Binding RNA Binding Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of DNA Recombination Transcription, DNA-templated RNA Processing MRNA Processing MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint	Immune Response Cell-cell Signaling
Pathways
Drugs
Diseases
GWAS		Bipolar disorder and major depressive disorder (combined) ( 20351715)
Protein-Protein Interactions		13 interactors: ALYREF DHX8 FRA10AC1 IK MOAP1 RABGEF1 RB1 SAP30BP SF3B2 THOC5 TRIM54 USHBP1 WDR77	19 interactors: APP CEP70 CHD3 CTNNBL1 FANCC FRA10AC1 GNB2L1 GRB2 KAT5 KDM1A MFAP1 NUP62 PFN2 RBM10 SUPT5H THOC1 TOE1 TTC14 ZCCHC10
Entrez ID		9984	3550
HPRD ID		09498	02771
Ensembl ID		ENSG00000079134	ENSG00000113141
Uniprot IDs		Q96FV9	Q13123 Q95HA6 Q9UK43
PDB IDs		1WXP
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Viral Process RNA Metabolic Process Gene Expression Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus Negative Regulation Of Kit Signaling Pathway RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Regulation Of Myeloid Leukocyte Differentiation Establishment Of Localization In Cell Nuclear Export MRNA Transport Regulation Of Centromere Complex Assembly Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Nucleobase-containing Compound Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Stem Cell Division Negative Regulation Of DNA Damage Checkpoint Maintenance Of Mitotic Sister Chromatid Cohesion Protein Insertion Into Mitochondrial Membrane Regulation Of Cohesin Localization To Chromatin Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development RNA Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Negative Regulation Of Interleukin-6 Secretion Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Mast Cell Degranulation Cellular Nitrogen Compound Metabolic Process Regulation Of MRNA Export From Nucleus Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Myeloid Cell Differentiation Cellular Localization Primitive Hemopoiesis Viral Life Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Intracellular Transport	Viral Process MRNA Processing Positive Regulation Of Cellular Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway MRNA Metabolic Process RNA Processing RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Viral Life Cycle Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cell Death Death Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of DNA-templated Transcription, Elongation Regulation Of Primitive Erythrocyte Differentiation Negative Regulation Of Isotype Switching To IgA Isotypes Regulation Of Protein Tyrosine Kinase Activity Regulation Of Cellular Protein Metabolic Process Chromatin Organization Regulation Of Phosphorylation Positive Regulation Of Cellular Component Biogenesis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Complex Assembly Cell Cycle RNA Splicing Negative Regulation Of Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of CAMP Catabolic Process Regulation Of Protein Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Phosphorus Metabolic Process Signal Transduction In Response To DNA Damage Organelle Organization Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated	ach additive atrial circuit conductances coupling electrotonic gc input muscarinic node nonlinear oxford oxsoft pacemaker passive potassium potentiate potentiated prolongation rc sa simulation sinoatrial spontaneous stopped sufficiently surrounding uk
Tagcloud (Difference) ?		biogenesis compromises conjunction coordinated degraded destabilization elongation evolutionarily export inspired mammals manipulated manipulation modest molecularly nascent nedd4 package proteasome reconstituted ribonucleoprotein rnp rnps specify tend transcripts ubiquitinated	ach additive atrial circuit conductances coupling electrotonic gc input muscarinic node nonlinear oxford oxsoft pacemaker passive potassium potentiate potentiated prolongation rc sa simulation sinoatrial spontaneous stopped sufficiently surrounding uk
Tagcloud (Intersection) ?