PJA2 and PRKAR2A

Number of citations of the paper that reports this interaction (PMID 21423175)
7

Data Source:
BioGRID (enzymatic study)

		PJA2	PRKAR2A
Gene Name		praja ring finger 2, E3 ubiquitin protein ligase	protein kinase, cAMP-dependent, regulatory, type II, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Postsynaptic Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome Ciliary Base
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination	Renal Water Homeostasis Energy Reserve Metabolic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: MAGED1 PRKAR1A PRKAR2A UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W	33 interactors: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP2 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CFTR EZR MAP2 MYCBPAP NBEA PJA2 PPP1CB PRKX RAB32 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1
Entrez ID		9867	5576
HPRD ID		11436	01484
Ensembl ID		ENSG00000198961	ENSG00000114302
Uniprot IDs		O43164	P13861 Q9BUB1
PDB IDs			2IZX 2KYG
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Innate Immune Response Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Innate Immune Response Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Response To Hypoxia Positive Regulation Of Transferase Activity Cellular Response To Decreased Oxygen Levels Protein K11-linked Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Oxygen Levels Response To Organic Substance Catabolic Process Negative Regulation Of Type I Interferon Production Immune System Process Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Stress Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Ubiquitin-protein Transferase Activity	Regulation Of Protein Kinase A Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Signaling Cellular Response To CAMP Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Communication Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Cellular Response To Stimulus Regulation Of Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Response To Stimulus Protein Localization Response To Purine-containing Compound Regulation Of Membrane Repolarization Regulation Of Signal Transduction Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cation Channel Activity Cellular Response To Organic Cyclic Compound Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Positive Regulation Of Protein Kinase A Signaling Regulation Of Potassium Ion Transmembrane Transport Response To CAMP Regulation Of Membrane Potential Positive Regulation Of Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity SMAD Protein Complex Assembly Response To Organophosphorus Regulation Of Delayed Rectifier Potassium Channel Activity Sexual Reproduction Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Potassium Ion Transport Epithelial Tube Morphogenesis Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transport Action Potential Tube Morphogenesis Regulation Of CAMP Biosynthetic Process Regulation Of Cellular Process Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus
Tagcloud ?		akap akap149 akaps camp complementary crc dependence destabilization e3 enzymatic exploiting fate generates igf1r ligase manipulation mechanistic opposing opposite organized osi pka praja2 respect subset survivin tgfbeta utilize xiap	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		akap akap149 akaps camp complementary crc dependence destabilization e3 enzymatic exploiting fate generates igf1r ligase manipulation mechanistic opposing opposite organized osi pka praja2 respect subset survivin tgfbeta utilize xiap	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?