PJA2 and PRKAR2A

Number of citations of the paper that reports this interaction (PubMedID 21423175)
0

Data Source:
BioGRID (enzymatic study)

		PJA2	PRKAR2A
Description		praja ring finger ubiquitin ligase 2	protein kinase cAMP-dependent type II regulatory subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Centriolar Satellite Ciliary Basal Body Synapse Glutamatergic Synapse	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Macrophage Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			GEM-231
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Frontotemporal dementia with GRN mutation ( 29724592) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Triglyceride levels ( 34074324)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: BBS2 KSR1 KSR2 MAGED1 MFHAS1 PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W WEE2-AS1	40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1
Entrez ID		9867	5576
HPRD ID		11436	01484
Ensembl ID		ENSG00000198961	ENSG00000114302
Uniprot IDs		O43164	A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861
PDB IDs			2IZX 2KYG 4ZP3 5H78 5XBY 8S8O
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity ATP Binding Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein-containing Complex Proteolysis Protein K11-linked Ubiquitination CAMP-dependent Protein Kinase Regulator Activity Protein Monoubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Modification Process Nucleotide-activated Protein Kinase Complex Proteasomal Protein Catabolic Process MAP-kinase Scaffold Activity TOR Signaling Protein Kinase A Catalytic Subunit Binding Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Catabolic Process Negative Regulation Of Signal Transduction CAMP Binding Regulation Of Intracellular Signal Transduction Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of CAMP/PKA Signal Transduction Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Raft	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus
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