PJA2 and UBE2J1

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		PJA2	UBE2J1
Description		praja ring finger ubiquitin ligase 2	ubiquitin conjugating enzyme E2 J1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Centriolar Satellite Ciliary Basal Body Synapse Glutamatergic Synapse	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Macrophage Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade	Protein Polyubiquitination Spermatid Development Regulation Of Macrophage Cytokine Production Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Regulation Of Tumor Necrosis Factor Production ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Frontotemporal dementia with GRN mutation ( 29724592) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Triglyceride levels ( 34074324)
Interacting Genes		16 interacting genes: BBS2 KSR1 KSR2 MAGED1 MFHAS1 PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W WEE2-AS1	50 interacting genes: AQP2 AQP6 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 SLC33A2 SLC71A2 SYVN1 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC UBR5
Entrez ID		9867	51465
HPRD ID		11436	15599
Ensembl ID		ENSG00000198961	ENSG00000198833
Uniprot IDs		O43164	Q9Y385
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity ATP Binding Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein-containing Complex Proteolysis Protein K11-linked Ubiquitination CAMP-dependent Protein Kinase Regulator Activity Protein Monoubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Modification Process Nucleotide-activated Protein Kinase Complex Proteasomal Protein Catabolic Process MAP-kinase Scaffold Activity TOR Signaling Protein Kinase A Catalytic Subunit Binding Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Catabolic Process Negative Regulation Of Signal Transduction CAMP Binding Regulation Of Intracellular Signal Transduction Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of CAMP/PKA Signal Transduction Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Raft	Membrane Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Endoplasmic Reticulum Membrane Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Protein Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Renal Water Transport Protein K48-linked Ubiquitination Transferase Activity Ubiquitin Ligase Complex Negative Regulation Of Response To Endoplasmic Reticulum Stress Protein K29-linked Ubiquitination Protein Modification Process
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