PJA2 and PRKAR1A

Number of citations: 0 (PubMedID 21423175)
Data Source: BioGRID (enzymatic study)

		PJA2	PRKAR1A
Name		praja ring finger ubiquitin ligase 2	protein kinase cAMP-dependent type I regulatory subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Centriolar Satellite Ciliary Basal Body Synapse Glutamatergic Synapse	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Macrophage Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		None	(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		None	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 29273807 ) Frontotemporal dementia with GRN mutation ( 29724592 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Triglyceride levels ( 34074324 )	Body size at age 10 ( 32376654 ) Coronary artery disease ( 33020668 ) Estimated glomerular filtration rate ( 31152163 ) Intake of total sugars ( 31005972 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		16 interacting genes: BBS2 KSR1 KSR2 MAGED1 MFHAS1 PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W WEE2-AS1	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		9867	5573
HPRD ID		11436	01786
Ensembl ID		ENSG00000198961	ENSG00000108946
Uniprot IDs		O43164	B2R5T5 P10644
PDB IDs		Not available	5KJX 5KJY 5KJZ
GO Terms Enriched among Interactors		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity ATP Binding Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein-containing Complex Proteolysis Protein K11-linked Ubiquitination CAMP-dependent Protein Kinase Regulator Activity Protein Monoubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Modification Process Nucleotide-activated Protein Kinase Complex Proteasomal Protein Catabolic Process MAP-kinase Scaffold Activity TOR Signaling Protein Kinase A Catalytic Subunit Binding Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Catabolic Process Negative Regulation Of Signal Transduction CAMP Binding Regulation Of Intracellular Signal Transduction Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of CAMP/PKA Signal Transduction Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Raft	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding