NUP58 and PKNOX1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid, two hybrid)

		NUP58	PKNOX1
Description		nucleoporin 58	PBX/knotted 1 homeobox 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Protein-containing Complex	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-containing Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nucleocytoplasmic Transport Protein Transport Regulation Of Protein Import Into Nucleus MRNA Transport	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS			Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		19 interacting genes: ABI3 AGR2 APC COG3 COG6 HTT KRT27 KRT28 KRT33B MAPK3 MEIS2 MIS18A NUP62 PKNOX1 PKNOX2 TRAF1 TRIM54 UBQLN1 UBQLN2	56 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3
Entrez ID		9818	5316
HPRD ID		06355	03653
Ensembl ID		ENSG00000139496	ENSG00000160199
Uniprot IDs		A0A8Q3WKK5 A0A8Q3WKL7 Q9BVL2	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs		4JO7 4JO9 4JQ5 5IJN 5IJO 7PER 7R5J 7R5K	1X2N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Localization To Centrosome Regulation Of Protein Localization To Centrosome Organelle Organization Regulation Of Macroautophagy Structural Constituent Of Skin Epidermis Intermediate Filament Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Golgi Transport Complex Retrograde Transport, Vesicle Recycling Within Golgi Anatomical Structure Morphogenesis Autophagosome Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Autophagosome Assembly Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Organelle Assembly Autophagosome Organization Regulation Of Organelle Organization Golgi Organization Regulation Of ERAD Pathway Positive Regulation Of Catabolic Process Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Hair Follicle Morphogenesis Identical Protein Binding Positive Regulation Of ERBB Signaling Pathway Intra-Golgi Vesicle-mediated Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Depolymerization Regulation Of Protein Catabolic Process Regulation Of Protein Stability Regulation Of Autophagy Intermediate Filament Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Microtubule Polymerization Or Depolymerization Cytoskeleton Epithelial Cell Differentiation Structural Molecule Activity Vacuole Organization Negative Regulation Of Store-operated Calcium Channel Activity Tissue Morphogenesis Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Peptidyl-tyrosine Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of G Protein-coupled Receptor Internalization	Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding
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