DDRGK1 and CFTR

Number of citations of the paper that reports this interaction (PubMedID 35156780)
96

Data Source:
BioGRID (protein complementation assay)

		DDRGK1	CFTR
Description		DDRGK domain containing 1	CF transmembrane conductance regulator
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Ligase Binding UFM1-modified Protein Reader Activity	Nucleotide Binding Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein-folding Chaperone Binding 14-3-3 Protein Binding Sec61 Translocon Complex Binding ABC-type Transporter Activity
	Biological Process	Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Reticulophagy Protein Localization To Endoplasmic Reticulum Protein Ufmylation Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum Protein K69-linked Ufmylation	Cholesterol Biosynthetic Process Monoatomic Ion Transport Chloride Transport Water Transport Vesicle Docking Involved In Exocytosis Bicarbonate Transport Cholesterol Transport Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal-level Water Homeostasis Intracellular PH Elevation Establishment Of Localization In Cell Transmembrane Transport Membrane Hyperpolarization Regulation Of Biological Quality Positive Regulation Of Enamel Mineralization Cellular Response To CAMP Amelogenesis Inorganic Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin
Pathways		RHOA GTPase cycle	ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOQ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy Developmental Lineage of Pancreatic Ductal Cells
Drugs			ATP Bumetanide Glyburide Ibuprofen Genistein Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor
Diseases			Hereditary pancreatitis; Hereditary chronic pancreatitis Cystic fibrosis (CF) Congenital bilateral absence of vas deferens
GWAS		HDL cholesterol levels x loop diuretics use interaction ( 31806883) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Night sleep phenotypes ( 27126917) Parkinson's disease ( 25064009 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Response to hepatitis C treatment ( 21659334) Ribavirin-induced anemia ( 20637204)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Type 1 diabetes ( 34012112) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: APP CFTR FBXO7 HTR6 KEAP1 TP53	466 interacting genes: A4GALT AARSD1 ABCC11 ABRAXAS1 ACCS ACOT8 ACRV1 ADAMTS1 ADAT1 ADCYAP1 ADRB3 AFMID AGBL4 AGO3 AHCYL1 AK8 AKR7A3 ALDOC ALKBH7 ANKRD49 ANKS3 ANTXR2 AP5B1 APOC2 AQP4-AS1 ARFGAP3 ARHGAP8 ARHGEF9 ARMC9 ASIC4 ASPDH ATOSB BACH1 BCAS1 BDH2 BEND5 BHLHA15 BICDL2 C19orf38 C1orf162 C7 C8orf33 C9orf43 CAB39L CABCOCO1 CALHM5 CALM2 CAMKK1 CAMKV CANX CAP1 CAPZB CASP1 CASQ2 CBR4 CCDC110 CCDC146 CCDC167 CCDC197 CCDC66 CCDC9 CCNYL6 CD22 CD68 CEP55 CFHR5 CGB2 CGB3 CGB5 CGB8 CGREF1 CHCHD10 CHMP2B CHRFAM7A CHRM4 CHRNA7 CHST14 CHST5 CIMIP5 CLCN3 CLCNKB CLEC10A CLEC12A CLEC7A CLIC1 COASY COL21A1 COL23A1 COL9A1 COPG1 COX18 CRABP1 CRACR2B CREB3L1 CSHL1 CSNK1G2-AS1 CUL1 CUTC CWC22 CYB561D1 CYP4F12 DACH2 DARS2 DAZ3 DAZ4 DDRGK1 DDX19A DDX20 DEF8 DEFB119 DEGS1 DERL1 DHX30 DLX6 DNAJA1 DNAJB14 DNAJC1 DNAJC5 DOCK10 DPF3 DPP7 DPPA3 DQX1 DRG1 DSTN DUSP7 EDF1 EEIG1 EFCAB11 EGLN3 EIF4E3 EMG1 ENPP5 EPHX1 EPO ERCC6L EREG ERICH5 ERMAP ETFA EVL EZR FAAP100 FABP2 FAM153CP FAM222A FAM9C FANCB FASTKD2 FBXO11 FCGR3A FCHO1 FGD5 FGL2 FHL2 FKBP6 FKBP6P2 FKBP7 FMOD FNIP1 FNTA GABRG2 GADD45B GAREM1 GCKR GCLM GDAP2 GFOD3P GGA1 GIMAP4 GINM1 GINS3 GNAS GNAZ GNB2 GOPC GPX1 GSDME GSTO1 GSTT2 GSTT2B GTF2F1 H2BC7 HACL1 HAND2-AS1 HAUS4 HDDC3 HEYL HHIPL2 HINT2 HK1 HMMR HNMT HOMER3 HSD17B2 HSP90AA1 HSPA14 HSPD1 HTATIP2 HTR5A IGKC IGKV1-5 IGKV2-24 IGLV4-3 IKZF2 IL12RB1 IL13 IL36A INHBA INIP INTU IQUB ISOC1 ITM2C JADE1 KATNAL1 KIF12 KLHDC7B KLHL18 KLK14 KPNA5 KRT13 KRT31 KRTAP26-1 LCMT1 LGALS14 LGALS2 LGALS9 LIAS LINC03042 LLCFC1 LMBR1L LMX1B LPCAT4 LRFN4 LRRC37B LRRC57 LSP1 LUM LURAP1L MAGEB2 MAGEC3 MAN1A1 MAP3K19 MARCHF2 MC3R MCCC2 MCPH1 MED11 MEIOB MELTF METTL14 METTL2A MGAT5B MGP MIER2 MORN3 MOS MPI MREG MRPS27 MSH4 MTFR2 MTMR14 MTRES1 MYADM MYEOV MYLK2 MYOG NAA10 NCCRP1 NEU4 NFAM1 NFIL3 NHERF1 NHERF2 NHERF4 NHLH2 NHS NIT2 NOD1 NOP53 NRIP3 NUDT1 OLFM4 OPTN OR5M8 OR7E91P OSTM1 OTC OTUD6A P2RY6 PBDC1 PBX3 PBX4 PCP4L1 PDHA1 PDIA3 PDS5B PDZK1 PGAP2 PIK3R5 PISD PLEKHB2 PNMA1 PNP POGLUT3 POLE POLR1F POU5F1 PPP1R21 PPP2R1B PRAF2 PRDM1 PRDM4 PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 PROKR1 PRSS45P PSMD4 PTCD1 PTTG1 PVRIG PWP2 PYROXD1 RASL10B RBM14 RDH12 RDH13 RFFL RFWD3 RGS13 RND3 RNF139 RNF5 RPS6KB2 RRS1 SAMD3 SAMD4B SAXO4 SCAMP1 SCN2B SDHA SDR9C7 SEC22C SEMA3E SERAC1 SERPINA3 SERPINA4 SERPINB10 SERPIND1 SERPING1 SH3BP4 SHC1 SLC10A1 SLC10A6 SLC14A1 SLC25A51P4 SLC26A11 SLC33A1 SLC35B4 SLC38A7 SLC44A5 SLC4A7 SLC4A8 SLC66A1LP SLC7A10 SLC9A6 SLC9B1 SMARCD1 SMIM21 SMYD1 SMYD3 SNAP23 SNRPN SORBS3 SOX15 SPATA6L SPEF1 SPSB3 SRP68 ST6GALNAC1 STAP2 STAU1 STIMATE STK26 STRADA STUB1 STX1A SYNE4 SYT12 TAFA3 TAFAZZIN TASL TBP TCTN3 TFEB TFF2 TFG TFR2 TGFB1 TGS1 THAP11 TIMD4 TK1 TLCD4 TLR3 TMEM237 TMEM277P TMEM40 TMPRSS6 TNFSF10 TONSL TOR1B TRAFD1 TRIM16 TRIM16L TRIM27 TRIM32 TRIM5 TRMT1 TSC22D1 TTR TXNRD2 UBE2I ULK3 UNC119 UNC45B UNC93B1 USP10 USP26 USP28 VAMP4 VAPA VAPB VASN VAV1 VDAC2 VEGFA VEPH1 VPS28 VPS4A VPS4B VTI1B WDR5B WWP2 XAGE3 XKR8 YTHDF1 ZBED2 ZC2HC1B ZDHHC15 ZFP57 ZFYVE26 ZGRF1 ZNF112 ZNF213 ZNF22 ZNF462 ZNF69 ZNF770 ZUP1
Entrez ID		65992	1080
HPRD ID		12741	03883
Ensembl ID		ENSG00000198171	ENSG00000001626
Uniprot IDs		Q96HY6	P13569
PDB IDs		7W3N 8B9X 8C0D 8OHD 8OJ0 8OJ5	1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1 6WBS 6ZE1 7QI1 7SV7 7SVD 7SVR 8EIG 8EIO 8EIQ 8EJ1 8FZQ 8GLS 8UBR 8V7Z 8V81 9DW4 9DW5 9DW7 9DW8 9DW9
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Protein-folding Chaperone Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Molecular Function Activator Activity Disordered Domain Specific Binding 14-3-3 Protein Binding Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Enzyme Binding Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Protein Heterodimerization Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Autophagy Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process Response To CAMP Protein Tetramerization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Developmental Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium
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