DDRGK1

Name	DDRGK domain containing 1
Structure
Novel Interactors	1 novel interactors: FASTKD5
Interactors	6 interactors: APP CFTR FBXO7 HTR6 KEAP1 TP53
GO Annotations	Cellular Component	Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Ligase Binding UFM1-modified Protein Reader Activity
	Biological Process	Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Migration Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Reticulophagy Protein Localization To Endoplasmic Reticulum Protein Ufmylation Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of I-kappaB Phosphorylation Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Localization To Endoplasmic Reticulum Protein K69-linked Ufmylation
Pathways	RHOA GTPase cycle
GWAS	HDL cholesterol levels x loop diuretics use interaction ( 31806883 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Night sleep phenotypes ( 27126917 ) Parkinson's disease ( 25064009 28892059 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Response to hepatitis C treatment ( 21659334 ) Ribavirin-induced anemia ( 20637204 )
Entrez ID	65992
HPRD ID	12741
Ensembl ID	ENSG00000198171
Uniprot IDs	Q96HY6
PDB IDs	7W3N 8B9X 8C0D 8OHD 8OJ0 8OJ5
GO Terms Enriched among Interactors ?	Protein-containing Complex Protein-folding Chaperone Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Molecular Function Activator Activity Disordered Domain Specific Binding 14-3-3 Protein Binding Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Neuron Apoptotic Process Enzyme Binding Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Protein Heterodimerization Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Autophagy Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Purine Nucleotide Metabolic Process Regulation Of MiRNA Metabolic Process Response To CAMP Protein Tetramerization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Developmental Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium