KEAP1 and DPP3

Number of citations of the paper that reports this interaction (PMID 23382044)
6

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		KEAP1	DPP3
Gene Name		kelch-like ECH-associated protein 1	dipeptidyl-peptidase 3
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Microtubule Organizing Center Cytosol Midbody Cul3-RING Ubiquitin Ligase Complex	Nucleoplasm Cytoplasm Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding	Protein Binding Metallopeptidase Activity Dipeptidyl-peptidase Activity Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Transcription, DNA-templated Proteasomal Ubiquitin-independent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Proteolysis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		38 interactors: AK4 AMER1 ATG5 BAD BPTF CAT CCNB1IP1 CLU DPP3 ETF1 FAM117B FAM46A GLRX5 GYPA IPO11 IRF1 KLHL3 KPNA6 LSM3 MAD2L1 MAPKBP1 MYO7A NFE2L2 NUDT4 OXR1 PDCD6IP PIDD1 PRKAG1 PRKCE PTMA RECK RELA SNRPN SQSTM1 TERF1 TSC22D4 WDR83 ZSCAN32	9 interactors: APP ATP5C1 HSPA8 KEAP1 LIG4 POT1 TERF1 TERF2IP TINF2
Entrez ID		9817	10072
HPRD ID		12079	06012
Ensembl ID		ENSG00000079999	ENSG00000254986
Uniprot IDs		Q14145	Q5JPB8 Q9NY33
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4IN4 4IQK	3FVY 3T6B 3T6J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Virus Positive Regulation Of Interleukin-12 Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Cellular Response To Nicotine Apoptotic Process Response To Other Organism Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Response To Biotic Stimulus Cell Death Death Regulation Of Interleukin-12 Biosynthetic Process ADP Metabolic Process Response To Reactive Oxygen Species Catabolic Process Cellular Macromolecule Catabolic Process Positive Regulation Of Mucus Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Response To Oxidative Stress Regulation Of Mucus Secretion Regulation Of Proteolysis Negative Regulation Of Cell Cycle Regulation Of Cell Division Regulation Of Type I Interferon Production Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Response To Hydrogen Peroxide Response To Drug Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Macrophage Activation Metabolic Process Regulation Of Wound Healing	Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of DNA Replication Regulation Of Chromosome Organization Cellular Nitrogen Compound Metabolic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Nitrogen Compound Metabolic Process DNA Replication Telomere Assembly Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Regulation Of DNA Replication Regulation Of Telomerase Activity Chromosome Organization DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome Homeostatic Process Regulation Of DNA Biosynthetic Process Neuron Apoptotic Process Regulation Of Organelle Organization Neuron Death Regulation Of Cellular Component Organization Biosynthetic Process Positive Regulation Of Organelle Organization Negative Regulation Of Protein ADP-ribosylation DNA Ligation Involved In DNA Recombination Negative Regulation Of Fibril Organization Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein ADP-ribosylation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Tagcloud ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Difference) ?		acceptable acts antioxidant antioxidants cytoprotective ech enhances exerted extensive h2o2 hydrogen interference kelch maintained managed ndds neurodegenerative neuroprotection neurotoxicity nrf2 oxidative peroxide relieving represses rnai sirna speculated suffered u87mg
Tagcloud (Intersection) ?