DPP3 and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		DPP3	TINF2
Description		dipeptidyl peptidase 3	TERF1 interacting nuclear factor 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Dipeptidyl-peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Proteolysis	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Neddylation KEAP1-NFE2L2 pathway	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Bipolar disorder ( 21926972)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		9 interacting genes: APP ATP5F1C CEBPA HSPA8 LIG4 POT1 TERF1 TERF2IP TINF2	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		10072	26277
HPRD ID		06012	16056
Ensembl ID		ENSG00000254986	ENSG00000092330
Uniprot IDs		Q9NY33	B4DFJ1 Q9BSI4
PDB IDs		3FVY 3T6B 3T6J 5E2Q 5E33 5E3A 5E3C 5EGY 5EHH 7OUP	3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Chromosome, Telomeric Region Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Telomere Organization Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of Protein Import Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Nucleobase-containing Compound Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Organelle Organization Nucleobase-containing Compound Metabolic Process Telomeric D-loop Disassembly Positive Regulation Of Cellular Component Organization Positive Regulation Of DNA Metabolic Process Regulation Of DNA Biosynthetic Process Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Cellular Component Organization Nucleic Acid Metabolic Process DNA Metabolic Process Cellular Response To Lithium Ion Response To Lithium Ion Regulation Of Cellular Component Organization Cellular Response To Metal Ion Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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