PROX1 and CTBP2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PROX1	CTBP2
Gene Name		prospero homeobox 1	C-terminal binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Transcriptional Repressor Complex Cell Junction Synapse
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Transcription Regulatory Region DNA Binding DBD Domain Binding LBD Domain Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Retinoic Acid Receptor Binding NAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Transcription From RNA Polymerase II Promoter Brain Development Circadian Rhythm Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Optic Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation	Transcription, DNA-templated Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Retinoic Acid Receptor Signaling Pathway White Fat Cell Differentiation Oxidation-reduction Process
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated repression of WNT target genes S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS		Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HIV-1 progression ( 20064070) Obesity ( 23818313)	Prostate cancer ( 18264096)
Protein-Protein Interactions		17 interactors: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3	67 interactors: ACTG1 AKTIP APP BAZ2B BCAS3 BCL3 C15orf39 CASP8AP2 CBX4 CCNH CCR5 CDKN2A CTBP1 CTPS2 DMRTB1 DVL2 EEF1D ELAC2 EP300 FHL3 FLI1 FOXP2 FUNDC1 HIC1 HIST3H3 HOXB5 IKZF1 IKZF2 KLF3 KLF8 LCOR MDM2 MECOM NOL4 NOL4L NRIP1 PLCB1 PNN PPP1R15A PROX1 PSMF1 RAI2 RBBP8 RIMBP3 RPL17 RPL7A RPS28 RPS29 RPS4X RUNX1 SOX13 SOX6 STUB1 STX11 TEAD3 TGIF1 TSHZ3 UBE2I XRCC6 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM1 ZFPM2 ZNF512B ZNF750
Entrez ID		5629	1488
HPRD ID		03330	04016
Ensembl ID		ENSG00000117707	ENSG00000175029
Uniprot IDs		Q92786	P56545 Q5SQP8
PDB IDs		2LMD	2OME
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Cellular Response To Lipid Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Lipid Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Hormone Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Signal Transduction Involved In Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Response To Hypoxia Signal Transduction	RNA Biosynthetic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Viral Process Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Embryo Development Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Developmental Process Cellular Process Multicellular Organismal Development Muscle Structure Development Muscle Organ Development Organ Development Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Difference) ?		allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole	acetylates acetylation corepressor correlating ctbps deacetylases demethylase dimerization ex527 exerts hdac hypoxic influencing interacted kdm1 ligation lsd1 microenvironmental modifying nscs pla proliferating proximity sensors sirt1 transferase unaltered undifferentiated
Tagcloud (Intersection) ?