GCH1 and GCHFR

Number of citations of the paper that reports this interaction (PubMedID 8702680)
0

Data Source:
HPRD (in vitro)

		GCH1	GCHFR
Description		GTP cyclohydrolase 1	GTP cyclohydrolase I feedback regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Dendrite Nuclear Membrane Melanosome
	Molecular Function	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding	Enzyme Inhibitor Activity Protein Binding GTP Cyclohydrolase Binding GTP Cyclohydrolase I Regulator Activity
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals	Negative Regulation Of Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanine
Diseases		Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)	Anxiety and stress-related disorders ( 31116379) Malaria ( 31844061) Triglycerides ( 30275531)
Interacting Genes		15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ	1 interacting genes: GCH1
Entrez ID		2643	2644
HPRD ID		02573	03895
Ensembl ID		ENSG00000131979	ENSG00000137880
Uniprot IDs		P30793 Q8IZH9	P30047
PDB IDs		1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ	6Z80 6Z85 7ACC 7AL9 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding	GTP Cyclohydrolase I Activity G-protein Beta/gamma-subunit Complex Regulation Of Lung Blood Pressure Positive Regulation Of Nitric-oxide Synthase Activity Tetrahydrofolate Biosynthetic Process Regulation Of Removal Of Superoxide Radicals Regulation Of Nitric-oxide Synthase Activity Tetrahydrobiopterin Biosynthetic Process Phosphatidylinositol Phospholipase C Activity Sensory Perception Of Bitter Taste Folic Acid-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Dopamine Biosynthetic Process Regulation Of Response To Reactive Oxygen Species Neuron Projection Terminus Response To Pain Catecholamine Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Mitogen-activated Protein Kinase Binding Pteridine-containing Compound Biosynthetic Process Tetrahydrofolate Metabolic Process Nitric Oxide Biosynthetic Process Nervous System Process Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Posture Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Neuronal Dense Core Vesicle Phospholipase C Activity Phosphatidylinositol-mediated Signaling G-protein Beta/gamma-subunit Complex Binding Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Folic Acid-containing Compound Metabolic Process Regulation Of Response To Oxidative Stress Nitric Oxide Metabolic Process Regulation Of Superoxide Metabolic Process Reactive Nitrogen Species Metabolic Process Diol Metabolic Process Dopamine Metabolic Process Positive Regulation Of Heart Rate Pteridine-containing Compound Metabolic Process Sensory Perception Of Taste Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Positive Regulation Of Heart Contraction Catecholamine Metabolic Process Phosphoric Diester Hydrolase Activity Negative Regulation Of Sequestering Of Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol System Process
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