SFI1 and LPXN

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SFI1	LPXN
Gene Name		Sfi1 homolog, spindle assembly associated (yeast)	leupaxin
Image
Gene Ontology Annotations	Cellular Component	Centriole Cytosol	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Phosphatase Binding	Transcription Cofactor Activity Protein Binding Zinc Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Negative Regulation Of Phosphatase Activity	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640)
Protein-Protein Interactions		12 interactors: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH KRT19 LPXN MAD2L2 MDFI RADIL SERTAD1	23 interactors: HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 MAP2K7 MAPK6 NDN PHF21A PLEKHH2 PLEKHN1 POM121 PTK2 PTK2B PTPN12 RUNX1T1 SFI1 TXLNB ZNF175 ZNF426
Entrez ID		9814	9404
HPRD ID		11550	05651
Ensembl ID		ENSG00000198089	ENSG00000110031
Uniprot IDs		A8K8P3	B7Z5P7 O60711
PDB IDs		2K2I	1X3H
Enriched GO Terms of Interacting Partners?		Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of DNA Binding Glycine Decarboxylation Via Glycine Cleavage System Positive Regulation Of Photoreceptor Cell Differentiation Regulation Of DNA Binding Negative Regulation Of Binding Embryonic Placenta Development	Regulation Of Cellular Process RNA Biosynthetic Process Signal Complex Assembly RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression MAPK Cascade Gene Expression Transcription, DNA-templated Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Cellular Response To Organic Substance Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epithelial Cell Migration Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell-matrix Adhesion Ameboidal-type Cell Migration Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Gene Expression Positive Regulation Of Kinase Activity Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Positive Regulation Of MAP Kinase Activity Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Response To Organic Substance Regulation Of Phosphatidylinositol 3-kinase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Abducens Nerve Formation Optokinetic Behavior Hsp90 Deacetylation Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Cell-matrix Adhesion
Tagcloud ?			7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5
Tagcloud (Difference) ?			7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5
Tagcloud (Intersection) ?