LPXN and RUNX1T1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		LPXN	RUNX1T1
Gene Name		leupaxin	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Image
Gene Ontology Annotations	Cellular Component	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Membrane Cell Projection Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Nuclear Matrix
	Molecular Function	Transcription Cofactor Activity Protein Binding Zinc Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of B Cell Receptor Signaling Pathway	Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640)
Protein-Protein Interactions		23 interactors: HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 MAP2K7 MAPK6 NDN PHF21A PLEKHH2 PLEKHN1 POM121 PTK2 PTK2B PTPN12 RUNX1T1 SFI1 TXLNB ZNF175 ZNF426	53 interactors: ABI3 ATN1 BCL6 BRCA1 C19orf57 CBFA2T3 CCDC36 CEP170P1 CPSF7 CREB3L1 DNMT1 EFHC2 EPS8 ETS1 GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HSP90AA1 ID1 ID3 KPNA1 KPNB1 LPXN LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 PCBD2 PRDM14 PRKAR2A SIN3A SPEN SPERT SPRY2 STX11 TAF9B TAL2 TCF12 TCF3 TCF4 TRIM42 UBQLN4 VDR WBP11 ZBTB16 ZMYM4 ZNF652
Entrez ID		9404	862
HPRD ID		05651	00590
Ensembl ID		ENSG00000110031	ENSG00000079102
Uniprot IDs		B7Z5P7 O60711	B2R6I9 Q06455
PDB IDs		1X3H	1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Process RNA Biosynthetic Process Signal Complex Assembly RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression MAPK Cascade Gene Expression Transcription, DNA-templated Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Cellular Response To Organic Substance Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epithelial Cell Migration Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell-matrix Adhesion Ameboidal-type Cell Migration Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Gene Expression Positive Regulation Of Kinase Activity Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Positive Regulation Of MAP Kinase Activity Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Response To Organic Substance Regulation Of Phosphatidylinositol 3-kinase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Abducens Nerve Formation Optokinetic Behavior Hsp90 Deacetylation Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Cell-matrix Adhesion	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Negative Regulation Of Gene Expression Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Multicellular Organismal Development Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Embryo Development Cellular Metabolic Process Organ Development Developmental Process Anatomical Structure Development System Development Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Differentiation Cellular Response To Organic Substance Rhythmic Process Organelle Organization Regulation Of Apoptotic Process
Tagcloud ?		7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5	accumulated aml aml201 cbfb cebpa chimeric clarify comprehensively cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations
Tagcloud (Difference) ?		7q31 arhh birc3 btk cav1 cav2 cd38 characterizing deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5	accumulated aml aml201 cbfb cebpa chimeric clarify cooperative cytogenetically cytogenetics dnmt3a exclusive flt3 impacts japan kit leukemianet mll myh11 npm1 precise ptd recurrently registered sole stratified translocations
Tagcloud (Intersection) ?		comprehensively