SFI1 and FAM131C

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SFI1	FAM131C
Gene Name		Sfi1 homolog, spindle assembly associated (yeast)	family with sequence similarity 131, member C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Centriole Cytosol
	Molecular Function	Protein Binding Phosphatase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Negative Regulation Of Phosphatase Activity
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		12 interactors: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH KRT19 LPXN MAD2L2 MDFI RADIL SERTAD1	10 interactors: APP DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1
Entrez ID		9814	348487
HPRD ID		11550	08779
Ensembl ID		ENSG00000198089	ENSG00000185519
Uniprot IDs		A8K8P3	Q96AQ9
PDB IDs		2K2I
Enriched GO Terms of Interacting Partners?		Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of DNA Binding Glycine Decarboxylation Via Glycine Cleavage System Positive Regulation Of Photoreceptor Cell Differentiation Regulation Of DNA Binding Negative Regulation Of Binding Embryonic Placenta Development	Neuron Recognition Neuromuscular Junction Development Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Metaphase Plate Congression Positive Regulation Of Glucocorticoid Receptor Signaling Pathway Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Developmental Cell Growth Synaptic Growth At Neuromuscular Junction Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Recognition Collateral Sprouting In Absence Of Injury Developmental Growth Involved In Morphogenesis Positive Regulation Of Peptidase Activity Cell Growth Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Proteolysis Synapse Organization Regulation Of Phosphorus Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Axon Choice Point Recognition Activation-induced Cell Death Of T Cells Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Neuron Remodeling Blastocyst Hatching Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Mitochondrial DNA Replication Negative Regulation Of Peptidase Activity Developmental Growth
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