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SFI1 and FAM131C
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
SFI1
FAM131C
Description
SFI1 centrin binding protein
family with sequence similarity 131 member C
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Centriole
Cytosol
Cytoskeleton
Molecular Function
Protein Binding
Phosphatase Binding
Protein Binding
Biological Process
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Age-related hearing impairment (
24939585
)
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Fish- and plant-related diet (
32066663
)
Lymphocyte count (
32888494
)
Metabolite levels (
23823483
)
Neutrophil percentage of white cells (
32888494
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Type 2 diabetes (
31118516
)
Cognitive performance (
19734545
)
Normal facial asymmetry (angle of surface orientation score) (
30631343
)
Interacting Genes
15 interacting genes:
CCDC120
CCDC57
CETN2
CRX
FAM131C
GCSH
GOLGA2
KRT19
LPXN
MAD2L2
MDFI
PPP1CA
RADIL
RBPMS
SERTAD1
12 interacting genes:
APP
CRYAA
DNAJA3
EWSR1
GRN
HPCAL4
LMO3
MAD1L1
NDN
SFI1
VSNL1
WWP2
Entrez ID
9814
348487
HPRD ID
11550
08779
Ensembl ID
ENSG00000198089
ENSG00000185519
Uniprot IDs
A8K8P3
Q96AQ9
PDB IDs
2K2I
Enriched GO Terms of Interacting Partners
?
Microtubule Organizing Center Organization
Telomere Maintenance In Response To DNA Damage
Centriole Replication
Cell Differentiation Involved In Embryonic Placenta Development
Centriole Assembly
Centriole
Microtubule Nucleation
Microtubule Cytoskeleton Organization
Cell Division
Astrocyte Activation Involved In Immune Response
Response To Heat
Astrocyte Activation
Central Nervous System Development
Response To Temperature Stimulus
Negative Regulation Of Signaling
Microglial Cell Activation
Negative Regulation Of Cell Communication
Leukocyte Activation Involved In Inflammatory Response
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Amylin Binding
Negative Regulation Of Protein Localization
Positive Regulation Of Toll Signaling Pathway
Neuron Recognition
Synapse Organization
Protein Stabilization
Positive Regulation Of Aspartic-type Peptidase Activity
MAD1 Complex
Regulation Of Cell Activation
Macrophage Activation
Acetylcholine Receptor Activator Activity
PTB Domain Binding
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Signal Transduction
Endosome To Plasma Membrane Transport Vesicle
Negative Regulation Of Signal Transduction
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Lipoprotein Particle
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Regulation Of Protein Stability
Negative Regulation Of Innate Immune Response
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Protein Folding
Positive Regulation Of Trophectodermal Cell Proliferation
Deactivation Of Mitotic Spindle Assembly Checkpoint
Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex
IkappaB Kinase Complex Binding
Type II Interferon Receptor Binding
Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Protein-folding Chaperone Binding
Positive Regulation Of Mitotic Cell Cycle
Response To Norepinephrine
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Tagcloud (Intersection)
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