LPXN and VCL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		LPXN	VCL
Description		leupaxin	vinculin
Image
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction	Podosome Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Cell-cell Junction Adherens Junction Zonula Adherens Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Myofibril Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Cell Projection Costamere Cell-cell Contact Zone Membrane Raft Perinuclear Region Of Cytoplasm Podosome Ring Extracellular Exosome Anchoring Junction Outer Dense Plaque Of Desmosome Inner Dense Plaque Of Desmosome Extracellular Vesicle Ficolin-1-rich Granule Lumen Terminal Web
	Molecular Function	Transcription Coregulator Activity Protein Binding Metal Ion Binding	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly	Morphogenesis Of An Epithelium Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Regulation Of Cell Migration Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction
Pathways			Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ALK fusions and activated point mutants Regulation of CDH1 Function High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)	Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426	38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP
Entrez ID		9404	7414
HPRD ID		05651	01900
Ensembl ID		ENSG00000110031	ENSG00000035403
Uniprot IDs		B7Z5P7 O60711	B3KXA2 P18206 V9HWK2
PDB IDs		1X3H 4XEF 4XEK 4XEV	1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW 7KTT 7KTU 7KTV 7KTW
Enriched GO Terms of Interacting Partners?		Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding	Anchoring Junction Focal Adhesion Vinculin Binding Cell-substrate Junction Assembly Cell-substrate Junction Organization Cell Junction Assembly Cell Adhesion Cytoskeleton Actin Filament Organization Cell Junction Organization Lamellipodium Supramolecular Fiber Organization Stress Fiber Cellular Component Assembly Focal Adhesion Assembly Actin Cytoskeleton Cytoplasm Cell-substrate Adhesion Integrin-mediated Signaling Pathway Cytoskeleton Organization Actin Binding Cell Motility Actin Filament Binding Cell Migration Signal Complex Assembly Integrin Binding Flotillin Complex Regulation Of Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Cytoskeleton Regulation Of Cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Anoikis Actin Cytoskeleton Organization Cardiac Muscle Thin Filament Assembly Cytoskeletal Protein Binding Regulation Of Actin Filament Organization Regulation Of Anoikis Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Actin Filament Plasma Membrane Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cytosol Positive Regulation Of Cytoskeleton Organization Cell Projection Adherens Junction Protein-containing Complex Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway
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