SFI1 and GCSH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SFI1	GCSH
Description		SFI1 centrin binding protein	glycine cleavage system protein H
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centriole Cytosol Cytoskeleton	Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex
	Molecular Function	Protein Binding Phosphatase Binding	Aminomethyltransferase Activity Protein Binding
	Biological Process		Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Glycine degradation Protein lipoylation
Drugs			6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		A body shape index ( 34021172) Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Fish- and plant-related diet ( 32066663) Lymphocyte count ( 32888494) Metabolite levels ( 23823483) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 31118516)	Glycine levels ( 30837465 31070104) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH GOLGA2 KRT19 LPXN MAD2L2 MDFI PPP1CA RADIL RBPMS SERTAD1	10 interacting genes: CIDEB ING5 MAGEA11 MAGEA6 MED11 MIS18A NMI RHBDD2 SFI1 ZBTB16
Entrez ID		9814	2653
HPRD ID		11550	01998
Ensembl ID		ENSG00000198089	ENSG00000140905
Uniprot IDs		A8K8P3	P23434
PDB IDs		2K2I
Enriched GO Terms of Interacting Partners?		Microtubule Organizing Center Organization Telomere Maintenance In Response To DNA Damage Centriole Replication Cell Differentiation Involved In Embryonic Placenta Development Centriole Assembly Centriole Microtubule Nucleation Microtubule Cytoskeleton Organization Cell Division
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