LPXN and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LPXN	PTPN12
Description		leupaxin	protein tyrosine phosphatase non-receptor type 12
Image
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection Anchoring Junction
	Molecular Function	Transcription Coregulator Activity Protein Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs			Tiludronic acid
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)	A body shape index ( 34021172) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte count ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426	57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		9404	5782
HPRD ID		05651	02513
Ensembl ID		ENSG00000110031	ENSG00000127947
Uniprot IDs		B7Z5P7 O60711	B4E105 Q05209
PDB IDs		1X3H 4XEF 4XEK 4XEV	5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?		Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding	Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Kinase Activity Signal Transduction Kinase Activity Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade ERBB Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Positive Regulation Of Signal Transduction Phosphorylation Receptor Complex Focal Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus ATP Binding Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Migration Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Phosphate Metabolic Process Perinuclear Region Of Cytoplasm Response To Growth Factor Positive Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Animal Organ Development Regulation Of Developmental Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion Insulin Receptor Substrate Binding Positive Regulation Of Protein Phosphorylation Anchoring Junction Positive Regulation Of Cellular Component Organization Positive Regulation Of Phosphorylation Regulation Of Cell Motility Positive Regulation Of Developmental Process
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