LPXN and PTK2B

Number of citations of the paper that reports this interaction (PubMedID 9565592)
0

Data Source:
HPRD (in vivo)

		LPXN	PTK2B
Description		leupaxin	protein tyrosine kinase 2 beta
Image
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Lamellipodium Cell Junction Dendrite Growth Cone Cell Projection Neuronal Cell Body Cell Body Perinuclear Region Of Cytoplasm Anchoring Junction Apical Dendrite Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Transcription Coregulator Activity Protein Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Signaling Receptor Activator Activity Ionotropic Glutamate Receptor Binding Neurotransmitter Receptor Regulator Activity
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly	Angiogenesis Neuron Migration Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Adaptive Immune Response Marginal Zone B Cell Differentiation Immune System Process Protein Phosphorylation Apoptotic Process Cellular Defense Response Cytoskeleton Organization Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Actin Filament Polymerization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of Neuron Apoptotic Process Bone Resorption Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Multicellular Organismal Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Protein-containing Complex Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Fluid Shear Stress Endothelin Receptor Signaling Pathway Regulation Of Postsynaptic Density Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of B Cell Chemotaxis
Pathways			Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway RHOU GTPase cycle Interleukin-2 signaling
Drugs			Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Fostamatinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)	Adult body size ( 32376654) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral content ( 31790847) Bone mineral density ( 31790847) Crohn's disease ( 26192919) Dental caries ( 23259602) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Family history of Alzheimer's disease ( 30617256) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Schizophrenia ( 29483656) Takayasu arteritis ( 30498034 25604533 33308445) White blood cell count ( 32888494)
Interacting Genes		33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426	70 interacting genes: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAP4K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70
Entrez ID		9404	2185
HPRD ID		05651	03131
Ensembl ID		ENSG00000110031	ENSG00000120899
Uniprot IDs		B7Z5P7 O60711	Q14289
PDB IDs		1X3H 4XEF 4XEK 4XEV	2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3F 4EKU 4H1J 4H1M 4R32 4XEF 4XEK 4XEV 5TO8 5TOB 6LF3 7PLL 8XOX 8YGX
Enriched GO Terms of Interacting Partners?		Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Focal Adhesion Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Plasma Membrane Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Adhesion Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Protein Kinase Activity Cytosol Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Positive Regulation Of Cell Adhesion Cell Activation Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Kinase Activity Growth Hormone Receptor Signaling Pathway Cell Migration Leukocyte Activation Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Junction Regulation Of Cell-cell Adhesion Response To Growth Factor T Cell Costimulation Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Anchoring Junction ERBB Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune System Process Cell Motility Cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Kinase Binding Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Tyrosine Kinase Binding
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