SFI1 and CCDC120

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SFI1	CCDC120
Gene Name		Sfi1 homolog, spindle assembly associated (yeast)	coiled-coil domain containing 120
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Centriole Cytosol
	Molecular Function	Protein Binding Phosphatase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Negative Regulation Of Phosphatase Activity
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH KRT19 LPXN MAD2L2 MDFI RADIL SERTAD1	18 interactors: BRCA1 CCDC102B CCDC57 CCDC85B CEP170P1 CYTH2 CYTH3 DAZAP2 EFHC2 KRT15 KRT31 KRT40 MDFI MID2 SFI1 TRAF1 USHBP1 ZDHHC17
Entrez ID		9814	90060
HPRD ID		11550	06595
Ensembl ID		ENSG00000198089	ENSG00000147144
Uniprot IDs		A8K8P3	A8K5Q5 B4DF24 B4DFC1 Q96HB5
PDB IDs		2K2I
Enriched GO Terms of Interacting Partners?		Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of DNA Binding Glycine Decarboxylation Via Glycine Cleavage System Positive Regulation Of Photoreceptor Cell Differentiation Regulation Of DNA Binding Negative Regulation Of Binding Embryonic Placenta Development	Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Histone H3-K9 Acetylation Regulation Of ARF Protein Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Indole-3-methanol Negative Regulation Of Biosynthetic Process Negative Regulation Of Centriole Replication Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Dosage Compensation By Inactivation Of X Chromosome Protein K6-linked Ubiquitination Protein Localization To Microtubule Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Metabolic Process Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Epidermis Development
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