LPXN and PHF21A

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LPXN	PHF21A
Gene Name		leupaxin	PHD finger protein 21A
Image
Gene Ontology Annotations	Cellular Component	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Membrane Cell Projection Perinuclear Region Of Cytoplasm	Histone Deacetylase Complex Nucleoplasm
	Molecular Function	Transcription Cofactor Activity Protein Binding Zinc Ion Binding	DNA Binding Chromatin Binding Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Suckling Behavior Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Chromatin Modification
Pathways			Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640)	Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		23 interactors: HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 MAP2K7 MAPK6 NDN PHF21A PLEKHH2 PLEKHN1 POM121 PTK2 PTK2B PTPN12 RUNX1T1 SFI1 TXLNB ZNF175 ZNF426	13 interactors: BANP FHL3 HDAC1 HDAC2 HIST2H3C HMG20B KDM1A KRT40 LPXN NUP62 RCOR1 TRAF1 ZYX
Entrez ID		9404	51317
HPRD ID		05651	10516
Ensembl ID		ENSG00000110031	ENSG00000135365
Uniprot IDs		B7Z5P7 O60711	Q96BD5
PDB IDs		1X3H	2PUY 2YQL
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Process RNA Biosynthetic Process Signal Complex Assembly RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression MAPK Cascade Gene Expression Transcription, DNA-templated Macromolecule Biosynthetic Process Signal Transduction By Phosphorylation Cellular Response To Organic Substance Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epithelial Cell Migration Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell-matrix Adhesion Ameboidal-type Cell Migration Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Kinase Activity Nucleobase-containing Compound Metabolic Process Regulation Of Immune System Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Gene Expression Positive Regulation Of Kinase Activity Regulation Of Immune Response Negative Regulation Of Biosynthetic Process Positive Regulation Of MAP Kinase Activity Cell-substrate Adhesion Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Response To Organic Substance Regulation Of Phosphatidylinositol 3-kinase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Abducens Nerve Formation Optokinetic Behavior Hsp90 Deacetylation Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Cell-matrix Adhesion	Blood Coagulation Hemostasis Histone H4 Deacetylation Regulation Of Body Fluid Levels Chromatin Modification Wound Healing Response To Wounding Chromatin Organization Regulation Of Transcription, DNA-templated Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Histone Deacetylation Protein Deacetylation RNA Biosynthetic Process Gene Expression Chromosome Organization Fungiform Papilla Formation Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Megakaryocyte Differentiation Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Fungiform Papilla Development Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Negative Regulation Of Cellular Metabolic Process Tongue Morphogenesis Histone Modification Regulation Of Receptor Biosynthetic Process RNA Metabolic Process Regulation Of Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Muscle Structure Development Macromolecule Biosynthetic Process Histone H3 Deacetylation Chromatin Remodeling Cellular Nitrogen Compound Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Signal Transduction Viral Process Negative Regulation Of Transcription, DNA-templated Tongue Development Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5	anaphase braf35 chromatid chromatids cohesin cohesion corepressor corest daughter demethlyase distribute esco2 establishment fused g9a gal4 hdac1 hdac2 k9 kept lsd1 methyltransferases possesses represses repressor segregation setdb1 sister suv39h1
Tagcloud (Difference) ?		7q31 arhh birc3 btk cav1 cav2 cd38 characterizing comprehensively deregulated distinguishes gng11 hampers homogenous igv ilf1 ltb mention pkca rel sell senataxin smzl smzls splenic syk tcl1 tma traf5	anaphase braf35 chromatid chromatids cohesin cohesion corepressor corest daughter demethlyase distribute esco2 establishment fused g9a gal4 hdac1 hdac2 k9 kept lsd1 methyltransferases possesses represses repressor segregation setdb1 sister suv39h1
Tagcloud (Intersection) ?