VGLL4 and LRRK1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		VGLL4	LRRK1
Description		vestigial like family member 4	leucine rich repeat kinase 1
Image
GO Annotations	Cellular Component	Nucleus	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Transcription Coactivator Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Negative Regulation Of Hippo Signaling Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cardiac Muscle Cell Proliferation	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa ( 21079607) Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Chronic obstructive pulmonary disease ( 30804561) Clopidogrel active metabolite levels ( 28207573) Height ( 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Moderate-to-late spontaneous preterm birth ( 31194736) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Relative hand skill in reading disability ( 24068947) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)
Interacting Genes		10 interacting genes: CDK6 DAPK1 LRRK1 LRRK2 MEF2A MEF2C MFHAS1 TEAD1 TEAD2 TERF2IP	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4
Entrez ID		9686	79705
HPRD ID		11672	14319
Ensembl ID		ENSG00000144560	ENSG00000154237
Uniprot IDs		A0A0A6YYI5 G5E9M9 Q14135	Q38SD2
PDB IDs		8YTF	8E04 8E05 8E06 8FAC
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction TEAD-YAP Complex Protein Serine Kinase Activity GTP Binding Syntaxin-1 Binding Mitochondrion Distribution Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Hippo Signaling Cellular Response To Metal Ion Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Kinase Activity Cellular Developmental Process MAPK Cascade Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Cyclin D2-CDK6 Complex DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death DNA-binding Transcription Factor Activity Mitochondrion Localization Excitatory Postsynaptic Potential Sinoatrial Valve Morphogenesis Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Stem Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Stress Cell Differentiation Cyclin D3-CDK6 Complex Regulation Of Gene Expression Cyclin D1-CDK6 Complex FBXO Family Protein Binding Cellular Response To Oxygen-containing Compound ERK5 Cascade Response To Metal Ion Animal Organ Development Cellular Response To Calcium Ion Muscle Cell Fate Determination Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Transmission, Glutamatergic Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Embryonic Heart Tube Morphogenesis	Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?