VGLL4 and MEF2A

Number of citations of the paper that reports this interaction (PMID 15140898)
17

Data Source:
BioGRID (two hybrid)

		VGLL4	MEF2A
Gene Name		vestigial-like family member 4	myocyte enhancer factor 2A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function		RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding SMAD Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Mitochondrial Genome Maintenance Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Apoptotic Process Heart Development Muscle Organ Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Myogenesis Toll Like Receptor 3 (TLR3) Cascade ERK/MAPK targets Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Anorexia nervosa ( 21079607) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000)
Protein-Protein Interactions		5 interactors: CDK6 MEF2A MEF2C TEAD1 TERF2IP	26 interactors: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 EP300 ERBB2IP HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4
Entrez ID		9686	4205
HPRD ID		11672	02807
Ensembl ID		ENSG00000144560	ENSG00000068305
Uniprot IDs		G5E9M7 Q14135	Q02078
PDB IDs			1C7U 1EGW 1LEW 3KOV 3MU6 3P57
Enriched GO Terms of Interacting Partners?		Primary Heart Field Specification Sinoatrial Valve Morphogenesis Regulation Of Synaptic Activity Cellular Response To Trichostatin A Nephron Tubule Epithelial Cell Differentiation Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Muscle Cell Fate Determination Positive Regulation Of Cell Proliferation In Bone Marrow Embryonic Heart Tube Morphogenesis Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Behavioral Fear Response Embryonic Heart Tube Development Ventricular Cardiac Myofibril Assembly Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Proliferation Regulation Of Osteoblast Differentiation Cardiac Ventricle Formation Cardiac Chamber Formation Germinal Center Formation Positive Regulation Of Alkaline Phosphatase Activity Regulation Of Macrophage Apoptotic Process Regulation Of Germinal Center Formation Glomerulus Morphogenesis Cellular Response To Fluid Shear Stress Secondary Heart Field Specification Mitochondrion Distribution Embryonic Viscerocranium Morphogenesis Regulation Of Sarcomere Organization Muscle Cell Fate Commitment Regulation Of Myeloid Cell Differentiation Monocyte Differentiation Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Megakaryocyte Differentiation Regulation Of Protein Homodimerization Activity Cartilage Morphogenesis Positive Regulation Of Cardiac Muscle Cell Differentiation Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Ventricular Cardiac Muscle Cell Development Cellular Response To Antibiotic Heart Formation Regulation Of Ossification Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Platelet Formation Mesenchyme Development Platelet Morphogenesis Cardiac Myofibril Assembly Specification Of Organ Identity Cellular Response To Toxic Substance Heart Morphogenesis	Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Fiber Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Skeletal Muscle Tissue Development Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Tissue Development Response To Organic Substance Regulation Of Cell Development Cardiovascular System Development Nitrogen Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Striated Muscle Tissue Development Response To Abiotic Stimulus Skeletal Muscle Tissue Development System Development Cellular Macromolecule Biosynthetic Process Developmental Process
Tagcloud ?			blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Difference) ?			blastula distinguished ectoderm ectopic embryo explants lie mef2d mesoderm myf5 myod myogenesis myogenic myosin neither pole precedes presumptive reciprocal rsrf skeletal sl1 sl2 somitic tailbud xenopus xmlc2 zygotic
Tagcloud (Intersection) ?