LRRK1 and SCEL

Number of citations: 77 (PubMedID 29513927)
Data Source: BioGRID (pull down)

		LRRK1	SCEL
Name		leucine rich repeat kinase 1	sciellin
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Cornified Envelope Cytoplasm Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Epidermis Development Response To Mechanical Stimulus Embryo Development Ending In Birth Or Egg Hatching Keratinocyte Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Height ( 28552196 ) Systemic lupus erythematosus ( 33272962 )	Chronotype ( 30696823 ) Craniofacial microsomia ( 26853712 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Morning person ( 30696823 )
Novel Interactors		2 novel interactors: SELENOS TM2D3	1 novel interactors: MYCBP2
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	13 interacting genes: APP DAPK1 FXR2 GOLGA2 KIFC3 LRRK1 LRRK2 MTUS2 NMI PTPRD TSC22D2 TSGA10 TXNIP
Entrez ID		79705	8796
HPRD ID		14319	09161
Ensembl ID		ENSG00000154237	ENSG00000136155
Uniprot IDs		Q38SD2	O95171
PDB IDs		8E04 8E05 8E06 8FAC	Not available
GO Terms Enriched among Interactors		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Identical Protein Binding Golgi-associated Vesicle Regulation Of Synapse Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Cytoskeleton Syntaxin-1 Binding Golgi Organization Microtubule Binding Positive Regulation Of Protein Ubiquitination Neuron Projection Positive Regulation Of Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Postsynapse Organization Positive Regulation Of Protein Modification Process Regulation Of Synapse Assembly Positive Regulation Of Inflammatory Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Regulation Of Protein Ubiquitination Amyloid-beta Complex Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Cytoplasm Modulation Of Excitatory Postsynaptic Potential DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Positive Regulation Of Catabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification Regulation Of Neuronal Synaptic Plasticity Regulation Of Canonical Wnt Signaling Pathway Microtubule Cytoskeleton Regulation Of Cell Junction Assembly Myeloid Cell Development