LRRK1 and SNX9

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK1	SNX9
Description		leucine rich repeat kinase 1	sorting nexin 9
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Ruffle Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cuticular Plate Cell Projection Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding 1-phosphatidylinositol Binding Lipid Binding Ubiquitin Protein Ligase Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Arp2/3 Complex Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Mitotic Cell Cycle Mitotic Cytokinesis Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Positive Regulation Of Actin Filament Polymerization Cleavage Furrow Formation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cell Division Lipid Tube Assembly Protein-containing Complex Assembly Plasma Membrane Tubulation Regulation Of Synaptic Vesicle Endocytosis
Pathways			Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	Borderline personality disorder ( 28632202) Heart rate response to beta blockers ( 29478026) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 23823483) Platelet distribution width ( 27863252 32888494)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	25 interacting genes: ADAM15 ADAM9 AP1G1 CEBPA CLTC DAPK1 DNM1 DNM2 EGFR FASLG ITCH KHDRBS1 LRRK1 MECOM MPHOSPH6 PAK2 PALS2 PI4KA PIK3CA PIK3R5 SOS1 SOS2 TNK2 WAS WASL
Entrez ID		79705	51429
HPRD ID		14319	12072
Ensembl ID		ENSG00000154237	ENSG00000130340
Uniprot IDs		Q38SD2	Q9Y5X1
PDB IDs		8E04 8E05 8E06 8FAC	2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE 7OJ9
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	SH3 Domain Binding Plasma Membrane Clathrin-coated Pit Vesicle Budding From Membrane Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Cytoplasmic Vesicle Regulation Of Plasma Membrane Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Endocytosis Immune System Process Clathrin-coated Vesicle Phosphatidylinositol 3-kinase Complex, Class IB Import Into Cell Intracellular Signaling Cassette Kinase Activity Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Focal Adhesion Regulation Of Hematopoietic Progenitor Cell Differentiation Cytosol Regulation Of Immune System Process Phosphatidylinositol 3-kinase Complex Regulation Of Pro-B Cell Differentiation Regulation Of Cellular Component Organization Extracellular Exosome Phosphatidylinositol 3-kinase Complex, Class IA Cytoplasm Actin Filament-based Movement Epidermal Growth Factor Receptor Signaling Pathway Transferrin Transport Receptor-mediated Endocytosis Positive Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Lymphoid Progenitor Cell Differentiation Protein Serine Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Receptor Internalization Cellular Response To Type II Interferon Vesicle-mediated Transport Regulation Of ERBB Signaling Pathway Regulation Of Protein Metabolic Process Protein Polymerization Eyelid Development In Camera-type Eye ERBB Signaling Pathway Insulin Receptor Signaling Pathway Apoptotic Process Regulation Of Macromolecule Metabolic Process
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