VGLL4 and TEAD2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		VGLL4	TEAD2
Name		vestigial like family member 4	TEA domain transcription factor 2
Structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol TEAD-YAP Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Negative Regulation Of Hippo Signaling Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cardiac Muscle Cell Proliferation	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Notochord Development Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Mesenchyme Development Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways		None	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Regulation of PD-L1(CD274) transcription
GWAS		Anorexia nervosa ( 21079607 ) Appendicular lean mass ( 33097823 ) Blond vs. brown/black hair color ( 30531825 ) Body mass index ( 28892062 ) Chronic obstructive pulmonary disease ( 30804561 ) Clopidogrel active metabolite levels ( 28207573 ) Height ( 25429064 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Male-pattern baldness ( 28196072 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Metabolite levels (HVA) ( 23319000 ) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000 ) Moderate-to-late spontaneous preterm birth ( 31194736 ) Offspring birth weight ( 31043758 ) Optic disc area ( 28073927 ) Relative hand skill in reading disability ( 24068947 ) Spontaneous preterm birth with premature rupture of membranes ( 31194736 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: CDK6 DAPK1 LRRK1 LRRK2 MEF2A MEF2C MFHAS1 TEAD1 TEAD2 TERF2IP	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		9686	8463
HPRD ID		11672	03432
Ensembl ID		ENSG00000144560	ENSG00000074219
Uniprot IDs		A0A0A6YYI5 G5E9M9 Q14135	Q15562
PDB IDs		8YTF	3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH 7OYJ 7T2J 7T2K 7T2L 7T2M 7TYP 7TYQ 7TYU 8CUH 8E1O 8P29 8POJ 8POM 8PON 8PUX 8PUY 8RXL 8RXP 8RXQ 8RXV 8RYC 8YGQ
GO Terms Enriched among Interactors		Intracellular Signal Transduction Signal Transduction TEAD-YAP Complex Protein Serine Kinase Activity GTP Binding Syntaxin-1 Binding Mitochondrion Distribution Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Hippo Signaling Cellular Response To Metal Ion Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Kinase Activity Cellular Developmental Process MAPK Cascade Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Cyclin D2-CDK6 Complex DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death DNA-binding Transcription Factor Activity Mitochondrion Localization Excitatory Postsynaptic Potential Sinoatrial Valve Morphogenesis Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Stem Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Stress Cell Differentiation Cyclin D3-CDK6 Complex Regulation Of Gene Expression Cyclin D1-CDK6 Complex FBXO Family Protein Binding Cellular Response To Oxygen-containing Compound ERK5 Cascade Response To Metal Ion Animal Organ Development Cellular Response To Calcium Ion Muscle Cell Fate Determination Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Transmission, Glutamatergic Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Embryonic Heart Tube Morphogenesis	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Process Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Epithelial Cell Proliferation Protein Serine Kinase Activity Regulation Of Cell Differentiation Cell Population Proliferation Regulation Of Developmental Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Signaling Pathway Developmental Process Negative Regulation Of Metabolic Process