LRRK1 and MTG1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK1	MTG1
Description		leucine rich repeat kinase 1	mitochondrial ribosome associated GTPase 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Ribosome Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Regulation Of Translation Regulation Of Respiratory System Process Regulation Of Mitochondrial Translation Mitochondrial Large Ribosomal Subunit Assembly
Pathways
Drugs
Diseases
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 24871463)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	10 interacting genes: APP DOCK8 ERICH1 KRT37 LRRK1 PICK1 PRNP RBFOX2 STRN4 STX2
Entrez ID		79705	92170
HPRD ID		14319	11602
Ensembl ID		ENSG00000154237	ENSG00000148824
Uniprot IDs		Q38SD2	Q9BT17
PDB IDs		8E04 8E05 8E06 8FAC	7O9K 7O9M 7PD3 8PK0 8QSJ
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Neuron Projection Organization Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Dendritic Spine Maintenance Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Response To Copper Ion Molecular Function Activator Activity Positive Regulation Of Receptor Internalization Response To Copper Ion Regulation Of Synaptic Plasticity Positive Regulation Of T Cell Migration Dendritic Spine Organization Postsynapse Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lymphocyte Migration Postsynapse Organization Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Amyloid-beta Regulation Of T Cell Migration Glial Cell Development Type 8 Metabotropic Glutamate Receptor Binding Memory T Cell Proliferation Myeloid Cell Development Regulation Of Lymphocyte Migration Cellular Component Maintenance Positive Regulation Of Neuron Apoptotic Process G Protein-coupled Receptor Binding Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Calcium-mediated Signaling Positive Regulation Of Mononuclear Cell Migration Protein-folding Chaperone Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production
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