LRRK1 and FAM184A

Number of citations: 77 (PubMedID 29513927)
Data Source: BioGRID (pull down)

		LRRK1	FAM184A
Name		leucine rich repeat kinase 1	family with sequence similarity 184 member A
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	P-body Extracellular Space Cytoplasm Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	None
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Height ( 28552196 ) Systemic lupus erythematosus ( 33272962 )	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Parkinson's disease progression (composite) ( 33111402 ) Parkinson's disease progression (motor) ( 33111402 ) Schizophrenia ( 30285260 )
Novel Interactors		2 novel interactors: SELENOS TM2D3	1 novel interactors: TBC1D32
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	11 interacting genes: AMOTL2 APP BRAP BRCA1 GOLGA2 LRRK1 LRRK2 MAP3K1 MTDH PPP1R13B VPS52
Entrez ID		79705	79632
HPRD ID		14319	09856
Ensembl ID		ENSG00000154237	ENSG00000111879
Uniprot IDs		Q38SD2	H7BY63 Q6P9G8 Q8NB25
PDB IDs		8E04 8E05 8E06 8FAC	Not available
GO Terms Enriched among Interactors		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Intracellular Signal Transduction Cellular Response To Manganese Ion Golgi-associated Vesicle Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Catecholamine Stimulus Signal Transduction Response To Catecholamine Response To Manganese Ion MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Cytoplasm Modulation Of Excitatory Postsynaptic Potential Identical Protein Binding Centrosome Cycle Syntaxin Binding MAPK Cascade Embryonic Ectodermal Digestive Tract Development Nuclear Membrane Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Tubulin Binding Myeloid Cell Development Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Endosome Cell Surface Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Histone H2AK127 Ubiquitin Ligase Activity P53 Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding PTB Domain Binding