LRRK1 and RAB29

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK1	RAB29
Description		leucine rich repeat kinase 1	RAB29, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Golgi Membrane Nucleoplasm Cytoplasm Mitochondrion Early Endosome Vacuole Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Organelle Membrane Nuclear Membrane Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Intracellular Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding Kinesin Binding Small GTPase Binding Dynein Complex Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Receptor Recycling Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitochondrion Organization Golgi Organization Synapse Assembly Response To Bacterium Negative Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Melanosome Organization T Cell Activation Retrograde Transport, Endosome To Golgi Host-mediated Perturbation Of Viral Process Positive Regulation Of T Cell Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Intracellular Protein Transport Protein Localization To Ciliary Membrane Regulation Of Retrograde Transport, Endosome To Golgi Cellular Detoxification
Pathways			RAB geranylgeranylation
Drugs
Diseases
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	9 interacting genes: BEND7 CRYAA CSTPP1 LDOC1 LRRK1 LSM7 REL TRIM27 TRIM32
Entrez ID		79705	8934
HPRD ID		14319	11962
Ensembl ID		ENSG00000154237	ENSG00000117280
Uniprot IDs		Q38SD2	B2R7I9 O14966 Q6FGU7
PDB IDs		8E04 8E05 8E06 8FAC	6HH2 8FO2 8FO8 8FO9
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Negative Regulation Of Type I Interferon Production Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Protein Polymerization Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Protein Localization To Phagocytic Vesicle
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