LRRK1 and GAK

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK1	GAK
Description		leucine rich repeat kinase 1	cyclin G associated kinase
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Anchoring Junction Presynapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Clathrin Binding Cyclin Binding Protein Folding Chaperone Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Protein Folding Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Intracellular Transport Clathrin Coat Assembly Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Regulation Of Clathrin Coat Assembly
Pathways			Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs			Fostamatinib
Diseases
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	A body shape index ( 34021172) HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 32310270 27182965 25064009 22438815 21738487 21292315) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	14 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1
Entrez ID		79705	2580
HPRD ID		14319	03631
Ensembl ID		ENSG00000154237	ENSG00000178950
Uniprot IDs		Q38SD2	B4DS37 O14976
PDB IDs		8E04 8E05 8E06 8FAC	4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Intracellular Transport Intracellular Protein Transport Clathrin Adaptor Complex Regulation Of Protein Localization Clathrin Adaptor Activity Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Low-density Lipoprotein Particle Receptor Binding Regulation Of Protein Import Trans-Golgi Network Membrane Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Vesicle Clathrin Coat Disassembly Regulation Of Protein Localization To Cell Periphery Vesicle Uncoating Regulation Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Clathrin-coated Pit P53 Binding Clathrin-coated Vesicle Establishment Of Protein Localization AP-1 Adaptor Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Endolysosome Membrane Transcytosis Cytosol Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine/threonine Kinase Binding Clathrin-coated Endocytic Vesicle Negative Regulation Of Macromolecule Biosynthetic Process Disordered Domain Specific Binding Regulation Of JNK Cascade Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process Positive Regulation Of Receptor Internalization Lysosomal Membrane Regulation Of Synaptic Vesicle Recycling Negative Regulation Of Protein Localization To Plasma Membrane Enzyme Binding Regulation Of Protein Localization To Nucleus Clathrin-dependent Endocytosis Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Component Assembly
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