LRRK1 and BAG1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		LRRK1	BAG1
Description		leucine rich repeat kinase 1	BAG cochaperone 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity	Adenyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding
	Biological Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction	Protein Folding Apoptotic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Protein Stabilization
Pathways			Regulation of HSF1-mediated heat shock response
Drugs			(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Diseases
GWAS		Central corneal thickness ( 28171582 29760442 31798171 32528159) Corneal structure ( 23291589) Height ( 28552196) Systemic lupus erythematosus ( 33272962)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4	31 interacting genes: AR ARRB1 BCL2 BCL2L1 CEBPA ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 LRRK1 LRRK2 MAPT MET NR3C1 OGT PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 UBC VDR
Entrez ID		79705	573
HPRD ID		14319	03292
Ensembl ID		ENSG00000154237	ENSG00000107262
Uniprot IDs		Q38SD2	A0A0S2Z3K4 Q99933
PDB IDs		8E04 8E05 8E06 8FAC	1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy	Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Macromolecule Metabolic Process Cytosol Ubiquitin Protein Ligase Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Signal Transduction Response To Hormone Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Nuclear Receptor Activity Regulation Of Apoptotic Process C3HC4-type RING Finger Domain Binding Positive Regulation Of Metabolic Process Signal Transduction Response To Steroid Hormone Identical Protein Binding Regulation Of Protein Modification Process ATP-dependent Protein Disaggregase Activity Cellular Response To Hormone Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Cellular Component Organization G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Mitochondrion Regulation Of Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Biological Quality Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Microtubule Polymerization Cellular Response To Steroid Hormone Stimulus
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