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VGLL4 and CDK6
Number of citations of the paper that reports this interaction (PMID
22094256
)
37
Data Source:
BioGRID
(enzymatic study)
VGLL4
CDK6
Gene Name
vestigial-like family member 4
cyclin-dependent kinase 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cyclin-dependent Protein Kinase Holoenzyme Complex
Ruffle
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Cyclin Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Positive Regulation Of Cell-matrix Adhesion
Type B Pancreatic Cell Development
Protein Phosphorylation
Cell Cycle Arrest
Notch Signaling Pathway
Negative Regulation Of Cell Proliferation
Response To Virus
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Astrocyte Development
Dentate Gyrus Development
Lateral Ventricle Development
T Cell Differentiation In Thymus
Gliogenesis
Cell Dedifferentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Myeloid Cell Differentiation
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Fibroblast Proliferation
Generation Of Neurons
Negative Regulation Of Epithelial Cell Proliferation
Cell Division
Hematopoietic Stem Cell Differentiation
Regulation Of Cell Motility
Negative Regulation Of Cellular Senescence
Pathways
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Anorexia nervosa (
21079607
)
Metabolite levels (HVA) (
23319000
)
Metabolite levels (HVA-5-HIAA Factor score) (
23319000
)
Height (
20881960
19343178
23563607
18391950
18391951
18391952
)
Rheumatoid arthritis (
18794853
)
White blood cell count (
20139978
21738479
)
White blood cell types (
21738478
)
Protein-Protein Interactions
5 interactors:
CDK6
MEF2A
MEF2C
TEAD1
TERF2IP
92 interactors:
ABI2
ANKRD12
AR
ATF6B
ATXN1
BCL11A
CASC3
CBY1
CCND1
CCND3
CDC37
CDC6
CDK7
CDKN1A
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CLASRP
CNOT7
CTNNB1
DAB1
DDIT3
DEDD2
EBF4
EIF4ENIF1
ELK1
EZH2
FOXM1
FOXO3
HIST1H1A
HSF1
ISL1
KIF26B
KLF10
LPIN1
MCM10
MCM2
MEF2D
MLLT3
MSL3
MYC
MZF1
N4BP1
NFATC3
NIPBL
NUMA1
PCNA
PML
POGZ
PPARGC1A
PPHLN1
PPM1B
PPP2CA
PRX
PSMA3
RB1
RBL1
RBL2
RBM23
RUNX1
SENP3
SIRT1
SLBP
SNIP1
SORBS1
SOX10
SOX5
SRSF1
SRSF11
SRSF12
SRSF2
SRSF7
SSBP2
SYNPO2
TCEB3B
TFDP1
TGFBR1
TJP2
TPX2
TRA2A
TRA2B
TRAK1
UHRF2
VGLL4
ZEB1
ZFP36
ZMYM3
ZNF101
ZNF174
ZNF335
ZSCAN1
Entrez ID
9686
1021
HPRD ID
11672
04533
Ensembl ID
ENSG00000144560
ENSG00000105810
Uniprot IDs
G5E9M7
Q14135
A4D1G0
Q00534
PDB IDs
1BI7
1BI8
1BLX
1G3N
1JOW
1XO2
2EUF
2F2C
3NUP
3NUX
4AUA
4EZ5
Enriched GO Terms of Interacting Partners
?
Primary Heart Field Specification
Sinoatrial Valve Morphogenesis
Regulation Of Synaptic Activity
Cellular Response To Trichostatin A
Nephron Tubule Epithelial Cell Differentiation
Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Muscle Cell Fate Determination
Positive Regulation Of Cell Proliferation In Bone Marrow
Embryonic Heart Tube Morphogenesis
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Behavioral Fear Response
Embryonic Heart Tube Development
Ventricular Cardiac Myofibril Assembly
Positive Regulation Of Protein Homodimerization Activity
Positive Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Osteoblast Differentiation
Cardiac Ventricle Formation
Cardiac Chamber Formation
Germinal Center Formation
Positive Regulation Of Alkaline Phosphatase Activity
Regulation Of Macrophage Apoptotic Process
Regulation Of Germinal Center Formation
Glomerulus Morphogenesis
Cellular Response To Fluid Shear Stress
Secondary Heart Field Specification
Mitochondrion Distribution
Embryonic Viscerocranium Morphogenesis
Regulation Of Sarcomere Organization
Muscle Cell Fate Commitment
Regulation Of Myeloid Cell Differentiation
Monocyte Differentiation
Cardiac Muscle Hypertrophy In Response To Stress
Regulation Of Megakaryocyte Differentiation
Regulation Of Protein Homodimerization Activity
Cartilage Morphogenesis
Positive Regulation Of Cardiac Muscle Cell Differentiation
Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Ventricular Cardiac Muscle Cell Development
Cellular Response To Antibiotic
Heart Formation
Regulation Of Ossification
Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Platelet Formation
Mesenchyme Development
Platelet Morphogenesis
Cardiac Myofibril Assembly
Specification Of Organ Identity
Cellular Response To Toxic Substance
Heart Morphogenesis
RNA Metabolic Process
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Cell Cycle
Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Cell Cycle Process
Positive Regulation Of Cellular Biosynthetic Process
Mitotic Cell Cycle
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Regulation Of Phosphorus Metabolic Process
Cellular Metabolic Process
RNA Processing
Regulation Of Protein Metabolic Process
Regulation Of Cellular Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdkn2a
cdkn2b
cdkn2c
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdkn2a
cdkn2b
cdkn2c
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?