VGLL4 and TEAD1

Number of citations of the paper that reports this interaction (PubMedID 15140898)
0

Data Source:
HPRD (in vitro)

		VGLL4	TEAD1
Description		vestigial like family member 4	TEA domain transcription factor 1
Image
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Negative Regulation Of Hippo Signaling Positive Regulation Of Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cardiac Muscle Cell Proliferation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Growth Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of MiRNA Transcription
Pathways			YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Anorexia nervosa ( 21079607) Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Chronic obstructive pulmonary disease ( 30804561) Clopidogrel active metabolite levels ( 28207573) Height ( 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Moderate-to-late spontaneous preterm birth ( 31194736) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Relative hand skill in reading disability ( 24068947) Spontaneous preterm birth with premature rupture of membranes ( 31194736)	Age at first sexual intercourse ( 34211149) Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 28552196) Hip circumference adjusted for BMI ( 34021172) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Rheumatic heart disease ( 34106200)
Interacting Genes		10 interacting genes: CDK6 DAPK1 LRRK1 LRRK2 MEF2A MEF2C MFHAS1 TEAD1 TEAD2 TERF2IP	20 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 YAP1 ZDHHC17
Entrez ID		9686	7003
HPRD ID		11672	01802
Ensembl ID		ENSG00000144560	ENSG00000187079
Uniprot IDs		A0A0A6YYI5 G5E9M9 Q14135	P28347 Q59EF3
PDB IDs		8YTF	2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5 7CMM 7ZJP 8Q68 9FZA 9GAX
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction TEAD-YAP Complex Protein Serine Kinase Activity GTP Binding Syntaxin-1 Binding Mitochondrion Distribution Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Hippo Signaling Cellular Response To Metal Ion Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Kinase Activity Cellular Developmental Process MAPK Cascade Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Cyclin D2-CDK6 Complex DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death DNA-binding Transcription Factor Activity Mitochondrion Localization Excitatory Postsynaptic Potential Sinoatrial Valve Morphogenesis Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Stem Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Cellular Response To Stress Cell Differentiation Cyclin D3-CDK6 Complex Regulation Of Gene Expression Cyclin D1-CDK6 Complex FBXO Family Protein Binding Cellular Response To Oxygen-containing Compound ERK5 Cascade Response To Metal Ion Animal Organ Development Cellular Response To Calcium Ion Muscle Cell Fate Determination Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Transmission, Glutamatergic Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Embryonic Heart Tube Morphogenesis	Protein Dimerization Activity DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Heart Development Positive Regulation Of Metabolic Process Histone Deacetylase Binding Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Carbon Catabolite Regulation Of Transcription Positive Regulation Of Developmental Growth Regulation Of Growth RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Heart Growth Embryonic Heart Tube Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Female Germ Cell Nucleus Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis Chromatin Cardiac Myofibril Assembly Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Muscle System Process Regulation Of Organ Growth Positive Regulation Of Growth Trophectodermal Cell Differentiation Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Epithelial Tube Morphogenesis Transcription Coactivator Activity Platelet Formation Muscle Organ Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process
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