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ZNF251 and MDC1
Number of citations of the paper that reports this interaction (PMID
22990118
)
7
Data Source:
BioGRID
(two hybrid)
ZNF251
MDC1
Gene Name
zinc finger protein 251
mediator of DNA-damage checkpoint 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Nucleoplasm
Chromosome
Focal Adhesion
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Metal Ion Binding
Protein Binding
Protein C-terminus Binding
FHA Domain Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Intra-S DNA Damage Checkpoint
Pathways
ATM mediated phosphorylation of repair proteins
ATM mediated response to DNA double-strand break
Homologous Recombination Repair
Homologous recombination repair of replication-independent double-strand breaks
Recruitment of repair and signaling proteins to double-strand breaks
Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions
5 interactors:
FEZ1
FEZ2
MDC1
PAXIP1
SMAD1
37 interactors:
ANAPC1
ATM
BARD1
BRCA1
CASP3
CENPC
CHEK2
COPS5
CREBBP
CSNK2A1
DTX2
EP300
GATA4
H2AFX
HDAC10
HDAC8
HINFP
LOC729324
NBN
NCL
PIAS1
PIAS4
PRIM1
RAD50
RAD51
RNF8
SMC1A
SUMO1
SUMO2
TP53
TP53BP1
UIMC1
USP28
VAMP5
WHSC1
WRN
ZNF251
Entrez ID
90987
9656
HPRD ID
19696
16252
Ensembl ID
ENSG00000198169
ENSG00000137337
Uniprot IDs
Q9BRH9
A1Z5I9
Q14676
PDB IDs
2ADO
2AZM
2ETX
3K05
3UEO
3UMZ
3UN0
3UNM
3UNN
3UOT
Enriched GO Terms of Interacting Partners
?
Regulation Of Dendrite Morphogenesis
Regulation Of Dendrite Development
Positive Regulation Of Histone H3-K36 Methylation
Anatomical Structure Morphogenesis
Positive Regulation Of Neuron Projection Development
DNA Recombination
Connective Tissue Development
Primary MiRNA Processing
Positive Regulation Of Cell Projection Organization
Locomotion
Osteoblast Fate Commitment
Chorion Development
Cellular Response To Stimulus
Positive Regulation Of Neuron Differentiation
Cell Differentiation
Intra-S DNA Damage Checkpoint
Movement Of Cell Or Subcellular Component
Regulation Of Neuron Projection Development
SMAD Protein Complex Assembly
Generation Of Neurons
Axon Guidance
Negative Regulation Of Macroautophagy
Positive Regulation Of Neurogenesis
Neurogenesis
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Mesodermal Cell Fate Commitment
Positive Regulation Of Histone H3-K4 Methylation
Establishment Of Mitochondrion Localization
Positive Regulation Of DNA-templated Transcription, Initiation
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
System Development
Cardiac Muscle Cell Proliferation
Positive Regulation Of Cell Development
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Histone Acetylation
Cellular Response To BMP Stimulus
Regulation Of DNA-templated Transcription, Initiation
Axonogenesis
Regulation Of Cellular Component Organization
Regulation Of Histone H3-K4 Methylation
Regulation Of Neuron Differentiation
Response To Stimulus
Positive Regulation Of Peptidyl-lysine Acetylation
Positive Regulation Of Isotype Switching
Positive Regulation Of Protein Acetylation
Mesodermal Cell Differentiation
Axon Development
Cellular Response To Growth Factor Stimulus
Cell Morphogenesis Involved In Neuron Differentiation
Cellular Response To DNA Damage Stimulus
DNA Repair
Cell Cycle Process
Double-strand Break Repair
DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cell Cycle
Cell Cycle Checkpoint
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Response To Stress
Cellular Nitrogen Compound Metabolic Process
Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Chromosome Organization
Positive Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
DNA Damage Checkpoint
Response To Radiation
Regulation Of Metabolic Process
DNA Recombination
Organelle Organization
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Response To DNA Damage Stimulus
Response To Abiotic Stimulus
Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Stress
Mitotic Cell Cycle Process
Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Cell Cycle
Regulation Of DNA Repair
Positive Regulation Of Response To DNA Damage Stimulus
Negative Regulation Of Cell Cycle
Cellular Metabolic Process
Cellular Protein Modification Process
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Mitotic Cell Cycle Checkpoint
Negative Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Chromatin Organization
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud
?
53bp1
atm
break
breaks
cajal
delays
dsb
dsbs
facilitates
facilitating
h2ax
impairs
joining
localizes
neurodegeneration
nhej
nonhomologous
partner
premature
rad51
repair
rnf8
scaffold
strand
tcab1
ubiquitylation
wd40
wdr79
wrap53beta
Tagcloud (Difference)
?
53bp1
atm
break
breaks
cajal
delays
dsb
dsbs
facilitates
facilitating
h2ax
impairs
joining
localizes
neurodegeneration
nhej
nonhomologous
partner
premature
rad51
repair
rnf8
scaffold
strand
tcab1
ubiquitylation
wd40
wdr79
wrap53beta
Tagcloud (Intersection)
?