IKBKE and NFKBIA

Number of citations of the paper that reports this interaction (PMID 10421793)
71

Data Source:
HPRD (in vitro)

		IKBKE	NFKBIA
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Protein Import Into Nucleus, Translocation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Cell Proliferation Regulation Of NF-kappaB Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Pathways		Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Signaling by the B Cell Receptor (BCR) NF-kB is activated and signals survival Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs p75NTR signals via NF-kB MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA p75 NTR receptor-mediated signalling MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS			Psoriasis ( 20953189 20953190)
Protein-Protein Interactions		21 interactors: AZI2 BIRC2 BIRC3 CDC37 CHUK FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA SIKE1 TANK TBK1 TICAM1 TRAF2 TRIM27 XIAP	87 interactors: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKAP IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PTPN1 PTPN13 RBX1 REL RELA RNF7 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO2 SUMO3 SUMO4 TBK1 TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 VCP ZNF212
Entrez ID		9641	4792
HPRD ID		05442	01235
Ensembl ID		ENSG00000143466	ENSG00000100906
Uniprot IDs		Q14164	P25963
PDB IDs			1IKN 1NFI
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Innate Immune Response Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-beta Production Response To Bacterium Intracellular Signal Transduction Regulation Of Interferon-beta Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Necrotic Cell Death Necrotic Cell Death NIK/NF-kappaB Signaling Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Signaling Type I Interferon Production Response To Virus Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Communication Response To Other Organism Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Biotic Stimulus Defense Response To Virus Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signal Transduction Cellular Response To Stimulus Negative Regulation Of Cell Death Cellular Metabolic Process Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Cellular Process Signaling Intracellular Signal Transduction Immune Response Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Cell Death Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Innate Immune Response Negative Regulation Of Apoptotic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Organic Substance Regulation Of Immune System Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Gene Expression Response To Growth Factor Regulation Of Cytokine Production Response To Stress Regulation Of Nitrogen Compound Metabolic Process Regulation Of Immune Response
Tagcloud ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization
Tagcloud (Difference) ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	1alpha advance aggressiveness biopsies cd31 collectively december dehydrogenase demands deregulated diffuse doi enhancing enzymes gapdh glyceraldehyde glycolytic hif hodgkin inactive leu lymphoma lymphomagenesis online promote publication traf2 transformed vascularization
Tagcloud (Intersection) ?