IKBKE and TICAM1

Number of citations of the paper that reports this interaction (PMID 12692549)
461

Data Source:
HPRD (in vivo)

		IKBKE	TICAM1
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	toll-like receptor adaptor molecule 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Cytosol Endosome Membrane Ripoptosome
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity	Signal Transducer Activity Protein Binding Protein Kinase Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of Protein Homodimerization Activity Positive Regulation Of Chemokine Biosynthetic Process Innate Immune Response Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Apoptotic Signaling Pathway
Pathways		Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	TRAF6 mediated induction of TAK1 complex TRIF-mediated TLR3/TLR4 signaling IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Activated TLR4 signalling Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS			Vitiligo ( 22561518)
Protein-Protein Interactions		21 interactors: AZI2 BIRC2 BIRC3 CDC37 CHUK FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA SIKE1 TANK TBK1 TICAM1 TRAF2 TRIM27 XIAP	23 interactors: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 UBQLN1
Entrez ID		9641	148022
HPRD ID		05442	06350
Ensembl ID		ENSG00000143466	ENSG00000127666
Uniprot IDs		Q14164	Q8IUC6
PDB IDs			3RC4
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Innate Immune Response Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-beta Production Response To Bacterium Intracellular Signal Transduction Regulation Of Interferon-beta Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Necrotic Cell Death Necrotic Cell Death NIK/NF-kappaB Signaling Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Signaling Type I Interferon Production Response To Virus Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Communication Response To Other Organism Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Biotic Stimulus Defense Response To Virus Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction	Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Type I Interferon Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Immune Response Regulation Of Cytokine Production Innate Immune Response Regulation Of Immune Response Regulation Of Interferon-beta Production Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune System Process Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response Positive Regulation Of Type I Interferon Production Immune System Process Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Interferon-beta Production Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Interferon-alpha Production Negative Regulation Of Cytokine Production Cellular Response To Stimulus Positive Regulation Of Protein Metabolic Process Signaling Cell Communication Apoptotic Process Programmed Cell Death
Tagcloud ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest
Tagcloud (Difference) ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hist3h3 hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest
Tagcloud (Intersection) ?