IKBKE and TRIM27

Number of citations of the paper that reports this interaction (PMID 16393995)
19

Data Source:
BioGRID (enzymatic study)

		IKBKE	TRIM27
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	tripartite motif containing 27
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Integral Component Of Plasma Membrane Membrane PML Body Retromer Complex Nuclear Membrane
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity	Nucleic Acid Binding DNA Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Metal Ion Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Adaptive Immune Response Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Spermatogenesis Cell Proliferation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Trimerization Protein K63-linked Ubiquitination Interferon-gamma Secretion Negative Regulation Of Calcium Ion Import Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Viral Release From Host Cell
Pathways		Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS			Platelet aggregation ( 20526338)
Protein-Protein Interactions		21 interactors: AZI2 BIRC2 BIRC3 CDC37 CHUK FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA SIKE1 TANK TBK1 TICAM1 TRAF2 TRIM27 XIAP	254 interactors: ABCA1 ABCF3 AEN AES AMOTL2 ARHGEF3 ARHGEF5 ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 BABAM1 BAG1 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C14orf105 C20orf195 CCDC102B CCDC87 CCDC92 CCDC94 CCHCR1 CDC20B CDC23 CDK18 CDKL3 CHCHD3 CHD4 CHUK CKS1B CLK2 CPNE2 CSRP2 CSRP2BP CWF19L2 DCX DDX6 DGCR6 DMRT3 DNMT1 DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4E EIF4E2 EPC1 FAM103A1 FAM110A FAM126B FAM193B FAM214A FAM214B FAM64A FAM83A FANCM FARS2 FBF1 FBXL19 FBXW5 FHL3 FLJ38668 FOXB1 FOXC2 FXYD6 GATAD2B GEM GFAP GFI1B GFM2 GLYCTK GNPDA2 GPANK1 GRB2 GTF2F1 HAUS1 HDAC1 HR IKBKB IKBKE ILK INPP5J IQCE IQUB JOSD1 KANSL1 KAT5 KCTD15 KCTD9 KIAA1683 KIF1A KIF9 KIFC3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMO1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MTMR6 MVP NCK2 NDE1 NDEL1 NEBL NEDD9 NEIL2 NEK6 NELFE NME7 NOTCH2NL NR1D2 NUDT21 OAS1 OTUB2 PIAS1 PIAS2 PIAS3 PIAS4 PLEKHN1 PML POLE2 POLR1C POLR3C PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF31 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L RAB29 RB1 RBM23 RBM41 RBX1 RCOR3 RHPN1 RIBC1 RNF213 RNF25 SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 TBC1D22B TBK1 TCEA2 TCHP TEAD4 TMSB4X TMSB4XP6 TP53 TPM3 TPRKB TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UCHL3 UCHL5 UHRF2 USE1 USP2 USP7 UTP23 VPS25 VPS28 WDYHV1 WT1-AS XPA ZBTB16 ZC2HC1C ZFC3H1 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF417 ZNF446 ZNF572 ZNF581 ZNF79
Entrez ID		9641	5987
HPRD ID		05442	15996
Ensembl ID		ENSG00000143466	ENSG00000204713
Uniprot IDs		Q14164	P14373
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Innate Immune Response Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-beta Production Response To Bacterium Intracellular Signal Transduction Regulation Of Interferon-beta Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Necrotic Cell Death Necrotic Cell Death NIK/NF-kappaB Signaling Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Signaling Type I Interferon Production Response To Virus Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Communication Response To Other Organism Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Biotic Stimulus Defense Response To Virus Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction	Protein Modification By Small Protein Conjugation Protein Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Cellular Metabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Biosynthetic Process Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Gene Expression Cell Cycle RNA Metabolic Process Cellular Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Mitotic Cell Cycle Catabolic Process Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Proteolysis Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Metabolic Process
Tagcloud ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	bolstered compacta da decreases deficiency degeneration dopamine dopaminergic dramatically exists linkage movement mptp neurodegenerative neuron neurotoxin nigra obvious parkinson pars pc12 pd promote protects rnai shared snpc substantia upregulated
Tagcloud (Difference) ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	bolstered compacta da decreases deficiency degeneration dopamine dopaminergic dramatically exists linkage movement mptp neurodegenerative neuron neurotoxin nigra obvious parkinson pars pc12 pd promote protects rnai shared snpc substantia upregulated
Tagcloud (Intersection) ?