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IKBKE and FKBP5
Number of citations of the paper that reports this interaction (PubMedID
14743216
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
IKBKE
FKBP5
Description
inhibitor of nuclear factor kappa B kinase subunit epsilon
FKBP prolyl isomerase 5
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Mitochondrial Membrane
Serine/threonine Protein Kinase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Kinase Activity
Transferase Activity
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
K48-linked Polyubiquitin Modification-dependent Protein Binding
Identical Protein Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
FK506 Binding
Isomerase Activity
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Biological Process
Activation Of Innate Immune Response
Response To Stress
Immune Response
DNA Damage Response
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Gene Expression
Positive Regulation Of Lipid Storage
Positive Regulation Of Type I Interferon Production
Response To Cytokine
Response To Type I Interferon
Response To Interferon-beta
Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein-containing Complex Assembly
MRNA Stabilization
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Interleukin-17-mediated Signaling Pathway
Cellular Response To Virus
Protein Folding
Response To Bacterium
Response To Cocaine
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Response To Alcohol
Pathways
SUMOylation of immune response proteins
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
ESR-mediated signaling
MECP2 regulates neuronal receptors and channels
Modulation of host responses by IFN-stimulated genes
Drugs
Fostamatinib
Diseases
GWAS
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Metabolite levels (
23823483
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
27399966
33272962
)
A body shape index (
34021172
)
Autoimmune thyroid disease (
32581359
)
Birth weight (
31043758
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Eosinophil count (
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Hip circumference adjusted for BMI (
34021172
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Offspring birth weight (
31043758
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
27863252
)
Interacting Genes
22 interacting genes:
AZI2
BIRC2
BIRC3
CDC37
CHUK
CYLD
DDX3X
FKBP5
HSP90AA1
HSP90AB1
IRF3
IRF5
KTN1
MBP
NFKBIA
RELA
RIPK1
SIKE1
TANK
TICAM1
TRIM27
XIAP
13 interacting genes:
APP
CEBPA
CHUK
ESR1
FES
HSF1
HSP90AA1
IKBKE
MCMBP
NR2C2
OGT
PGR
STIP1
Entrez ID
9641
2289
HPRD ID
05442
04019
Ensembl ID
ENSG00000263528
ENSG00000096060
Uniprot IDs
A0A075B7B4
Q14164
Q13451
Q2TA84
PDB IDs
1KT0
3O5D
3O5E
3O5F
3O5G
3O5I
3O5J
3O5K
3O5L
3O5M
3O5O
3O5P
3O5Q
3O5R
4DRH
4DRI
4DRK
4DRM
4DRN
4DRO
4DRP
4DRQ
4JFI
4JFJ
4JFK
4JFL
4JFM
4R0X
4TW6
4TW7
4TX0
4W9O
4W9P
4W9Q
5BXJ
5DIT
5DIU
5DIV
5NJX
5OBK
5OMP
6SAF
6TX4
6TX5
6TX6
6TX7
6TX8
6TX9
6TXX
7A6W
7A6X
7AOT
7AOU
7APQ
7APS
7APT
7APW
7AWF
7AWX
7B9Y
7B9Z
7BA0
7ETT
7ETU
7ETV
7L7I
7R0L
8BA6
8BAJ
8CCA
8CCB
8CCC
8CCD
8CCE
8CCF
8CCG
8CCH
8CHN
8CHP
8CHQ
8CHR
8FFW
8PC2
8PJ8
8PJA
8R5K
9EU6
9EU7
9EU8
9EU9
9EUA
9EUB
9EUC
9EUD
9EUE
9EY3
9EY4
9GPK
9GPL
9GPM
9GPN
9GPO
9GPP
9GPQ
9GPR
9GPS
9GPT
9GPU
9GPV
9GPW
9GPX
9GPY
9GPZ
9GQ2
9GQ3
9GQ4
9GQ5
9GQ6
9GQ7
9GQ8
9GQ9
9GQA
9GQB
9GQC
9GQD
9GQE
9GQF
9GQG
9GQH
9GQI
9GQJ
9GQK
Enriched GO Terms of Interacting Partners
?
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Innate Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Positive Regulation Of Cytokine Production
Activation Of Innate Immune Response
Regulation Of Post-translational Protein Modification
Regulation Of Defense Response
Pattern Recognition Receptor Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Response To External Biotic Stimulus
Innate Immune Response-activating Signaling Pathway
Cytokine-mediated Signaling Pathway
Positive Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Receptor Signaling Pathway
Regulation Of Protein Modification Process
Positive Regulation Of Metabolic Process
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Biosynthetic Process
Response To Stress
Response To Virus
Regulation Of Apoptotic Process
Regulation Of Immune Response
Activation Of Immune Response
Regulation Of Programmed Cell Death
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Gene Expression
Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Non-canonical NF-kappaB Signal Transduction
Defense Response
Immune Response-activating Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Response To Other Organism
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Intracellular Signal Transduction
Immune Response-regulating Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Gene Expression
Positive Regulation Of Multicellular Organismal Process
Protein-containing Complex
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Response To Peptide
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
IkappaB Kinase Activity
Protein Folding Chaperone Complex
Positive Regulation Of Immune System Process
Positive Regulation Of Nitric Oxide Biosynthetic Process
Response To Hormone
Positive Regulation Of Nitric Oxide Metabolic Process
Response To Nutrient
Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Nuclear Receptor Activity
Regulation Of Protein-containing Complex Assembly
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Regulation Of Nitric Oxide Metabolic Process
Sequence-specific DNA Binding
Nitric-oxide Synthase Regulator Activity
Regulation Of Defense Response
Positive Regulation Of Metabolic Process
Chromatin Binding
Cellular Response To Virus
Negative Regulation Of RNA Metabolic Process
STAT Family Protein Binding
Estrogen Response Element Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Cytokine
Chromatin DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Type I Interferon Production
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Xenobiotic Stimulus
Nucleus
Nucleoplasm
Regulation Of Canonical NF-kappaB Signal Transduction
DNA-binding Transcription Factor Activity
Lipid Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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