IKBKE and FKBP5

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		IKBKE	FKBP5
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	FK506 binding protein 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Nucleoplasm Endoplasmic Reticulum Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding FK506 Binding Heat Shock Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Type I Interferon Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Protein Peptidyl-prolyl Isomerization Protein Folding Chaperone-mediated Protein Folding
Pathways		Activated TLR4 signalling TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated IRF7 activation MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: AZI2 BIRC2 BIRC3 CDC37 CHUK FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA SIKE1 TANK TBK1 TICAM1 TRAF2 TRIM27 XIAP	10 interactors: APP CHUK ESR1 FES HSF1 HSP90AA1 IKBKE NR2C2 PGR STIP1
Entrez ID		9641	2289
HPRD ID		05442	04019
Ensembl ID		ENSG00000143466	ENSG00000096060
Uniprot IDs		Q14164	Q13451 Q2TA84
PDB IDs			1KT0 3O5D 3O5E 3O5F 3O5G 3O5I 3O5J 3O5K 3O5L 3O5M 3O5O 3O5P 3O5Q 3O5R 4DRH 4DRI 4DRK 4DRM 4DRN 4DRO 4DRP 4DRQ 4JFI 4JFJ 4JFK 4JFL 4JFM
Enriched GO Terms of Interacting Partners?		Regulation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Innate Immune Response Defense Response Immune Response-regulating Signaling Pathway Regulation Of Immune System Process Immune System Process Positive Regulation Of Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Type I Interferon Production I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-beta Production Response To Bacterium Intracellular Signal Transduction Regulation Of Interferon-beta Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Necrotic Cell Death Necrotic Cell Death NIK/NF-kappaB Signaling Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Protein Metabolic Process Signaling Type I Interferon Production Response To Virus Positive Regulation Of NF-kappaB Transcription Factor Activity Cell Communication Response To Other Organism Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Response To Biotic Stimulus Defense Response To Virus Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Positive Regulation Of Intracellular Signal Transduction	Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Branching Involved In Pregnancy Positive Regulation Of Transcription, DNA-templated Defense Response Steroid Hormone Mediated Signaling Pathway Mammary Gland Epithelium Development Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Gene Expression I-kappaB Phosphorylation Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Response To Stimulus System Development Reproduction Mammary Gland Epithelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Mammary Gland Development Cellular Response To Steroid Hormone Stimulus Regulation Of Cellular Response To Heat Cellular Response To Stimulus Multicellular Organismal Development Immune Response DNA-templated Transcription, Initiation Anatomical Structure Development Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Reproductive Process Protein Phosphorylation Response To Stress Female Pregnancy Regulation Of Nitric-oxide Synthase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Anatomical Structure Morphogenesis Signal Transduction Branching Involved In Mammary Gland Duct Morphogenesis Response To Organic Substance Sexual Reproduction Developmental Process Multicellular Organismal Reproductive Process I-kappaB Kinase/NF-kappaB Signaling
Tagcloud ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	12q13 4x10 bd bdi bdnf beck bipolar dbh depression depressive dhh etiology gwas gwass gxe interplay inventory marginally mdd pcorrected personality puncorrected rs4523957 rs7296288 scz slc6a4 sles stressful unsuccessful
Tagcloud (Difference) ?		accelerate adherent bc canonical consequently cooperated cooperation efficiently eventually her2 ikkepsilon incurable ink4a kill kinome knock lapatinib lenti neoadjuvant nfkb potentiate senescence shrna succumb suppress tbk1 tumorspheres urgent xenograft	12q13 4x10 bd bdi bdnf beck bipolar dbh depression depressive dhh etiology gwas gwass gxe interplay inventory marginally mdd pcorrected personality puncorrected rs4523957 rs7296288 scz slc6a4 sles stressful unsuccessful
Tagcloud (Intersection) ?